Results 111 to 120 of about 1,875,358 (236)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Stability and approximations of eigenvalues and eigenfunctions of the Neumann Laplacian, part 3

Electronic Journal of Differential Equations, 2011
This article is a sequel to two earlier articles (one of them written jointly with R. Banuelos) on stability results for the Neumann eigenvalues and eigenfunctions of domains in $mathbb{R}^2$ with a snowflake type fractal boundary.
Michael M. H. Pang
doaj  

On the Sequence of Errors in Best Polynomial Approximation

Journal of Approximation Theory, 1997
A classic theorem of Bernstein shows that for any sequence of numbers \(\{a_i\}\) decreasing to zero, there is an \(f\in C[-1,1]\) such that \(E_n(f)=a_n\), where \(E_n(f)\) is the distance from \(f\) to the polynomials of degree not exceeding \(n\).
openaire   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Viscosity extragradient with modified inertial method for solving equilibrium problems and fixed point problem in Hadamard manifold

Journal of Inequalities and Applications
In this article, we propose a viscosity extragradient algorithm together with an inertial extrapolation method for approximating the solution of pseudomonotone equilibrium and fixed point problem of a nonexpansive mapping in the setting of a Hadamard ...
P. V. Ndlovu, L. O. Jolaoso, M. Aphane, H. A. Abass   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Decomposition of approximately monotone and convex sequences

Publicationes Mathematicae Debrecen
In this paper, we primarily deal with approximately monotone and convex sequences. We start by showing that any sequence can be expressed as the difference of two nondecreasing sequences. One of these two monotone sequences acts as the majorant of the original sequence, while the other possesses non-negativity.
openaire   +2 more sources

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Satellite Constellation Reconfiguration Using the Approximating Sequence Riccati Equations [PDF]

In this work we study the reconfiguration of a constellation of satellite. In this work we consider the non-linearfeedback optimal control of the motion of a spacecraft under the influence of the gravitational attraction of a centralbody, the Earth in ...
Owis, Ashraf H.
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source