Results 31 to 40 of about 1,875,358 (236)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Smooth approximation of the minimum function from below (and above)
Journal of Inequalities and ApplicationsWe provide an increasing approximating sequence of smooth lower bounds for the minimum of n ≥ 2 $n\geq 2$ real numbers, with exponential convergence.
Thomas A. Weber
doaj +1 more source
Abstract and Applied Analysis, 2012 We introduce an iterative method for finding a common fixed point of a countable family of multivalued quasi-nonexpansive mapping {Ti} in a uniformly convex Banach space. We prove that under certain control conditions, the iterative sequence generated by
Aunyarat Bunyawat, Suthep Suantai
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The Beesack-Darst-Pollard Inequalities and Approximation of the Riemann-Stieltjes Integral [PDF]
, 2007 Utilising the Beesack version of the Darst-Pollard inequality, some error bounds for approximating the Riemann-Stieltjes integral are given.
Dragomir, Sever S, Barnett, Neil S
core +5 more sources
Local transformations with a singular wavelet
Informatika, 2020 The paper considers a local wavelet transform with a singular basis wavelet. The problem of nonparametric approximation of a function is solved by the use of the sequence of local wavelet transforms.
V. M. Romanchak
doaj +1 more source
Approximating method of frames [PDF]
, 2003 In this paper, the well-known method of frames approach to the signal decomposition problem is reformulated as a certain bilevel goal-attainment linear least squares problem.
Marti-Lopez, Felipe, Koenig, Thomas
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Tykhonov well-posedness of elliptic variational-hemivariational inequalities
Electronic Journal of Differential Equations, 2019 We consider a class of elliptic variational-hemivariational inequalities in an abstract Banach space for which we introduce the concept of well-posedness in the sense of Tykhonov.
Mircea Sofonea, Yi-Bin Xiao
doaj