Results 61 to 70 of about 22,837 (216)

Theoretical limit of link prediction using a combination method

Tongxin xuebao, 2020
The problem that whether there a theoretical limit exists for link prediction combination methods and how to approximate was investigated.Link prediction methods were divided into single or combination methods,based on whether multidimension information ...
Yiteng WU, Hongtao YU, Ruiyang HUANG, Huawei LI   +3 more
doaj   +2 more sources

Global Sampling for Sequential Filtering over Discrete State Space

EURASIP Journal on Advances in Signal Processing, 2004
In many situations, there is a need to approximate a sequence of probability measures over a growing product of finite spaces. Whereas it is in general possible to determine analytic expressions for these probability measures, the number of computations
Cheung-Mon-Chan Pascal, Moulines Eric
doaj   +1 more source

On a New Reliable Algorithm

International Journal of Differential Equations, 2009
An analytical expression for the solution of the prey-predator problem by an adaptation of the homotopy analysis method (HAM) is presented. The HAM is treated as an algorithm for approximating the solution of the problem in a sequence of time intervals ...
A. K. Alomari, M. S. M. Noorani, R. Nazar   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A note on the three-way generalization of the Jordan canonical form

Open Mathematics, 2018
The limit point 𝓧 of an approximating rank-R sequence of a tensor Ƶ can be obtained by fitting a decomposition (S, T, U) ⋅ 𝓖 to Ƶ. The decomposition of the limit point 𝓧 = (S, T, U) ⋅ 𝓖 with 𝓖 = blockdiag(𝓖1, … , 𝓖m) can be seen as a three order ...
Cui Lu-Bin, Li Ming-Hui
doaj   +1 more source