Results 91 to 100 of about 4,720,579 (297)

Efficient Likelihood Evaluation of State-Space Representations [PDF]

We develop a numerical procedure that facilitates efficient likelihood evaluation in applications involving non-linear and non-Gaussian state-space models.
David N. DeJong, Guilherme Moura, Hariharan Dharmarajan, Roman Liesenfeld, Jean-Francois Richard   +4 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Bi-Fuzzy S-Approximation Spaces

Mathematics
The S-approximation spaces are significant extension of the rough set model and have been widely applied in intelligent decision-making. However, traditional S-approximation spaces are limited to two crisp universes, whereas bi-fuzzy universes (i.e., two
Ronghai Wang, Xiaojie Xie, Huilai Zhi
doaj   +1 more source

Rate of convergence by Kantorovich-Szász type operators based on Brenke type polynomials

Journal of Inequalities and Applications, 2017
The present paper deals with the approximation properties of the univariate operators which are the generalization of the Kantorovich-Szász type operators involving Brenke type polynomials.
Tarul Garg, Purshottam Narain Agrawal, Serkan Araci   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

An Example on Sobolev Space Approximation [PDF]

Bulletin of the London Mathematical Society, 1997
For each \(d\geq 2\) we construct a connected open set \(\Omega \subset \mathbb{R}^d\) such that \(\Omega= \text{int(clos} (\Omega))\) and for each \(k\geq 1\) and each \(p\in [1,+ \infty)\), the subset \(W^{k, \infty} (\Omega)\) fails to be dense in the Sobolev space \(W^{k, p} (\Omega)\), in the norm of \(W^{k, p} (\Omega)\).
openaire   +3 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Weak Approximation Properties Induced by Unconditionally p-Compact Sets

Mathematics
This paper investigates several equivalent formulations of the unconditionally p-approximation property. Inspired by these formulations, we introduce a new approximation property, called the weak unconditionally p-approximation property, and develop a ...
Ayşegül Keten Çopur
doaj   +1 more source