Results 61 to 70 of about 159,150 (262)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Dimension-Independent Approximations on Low-Dimensional Manifolds Using Transformers
MathematicsDeep neural networks have been remarkably successful in high-dimensional learning and scientific computing, often succeeding where classical discretization methods fail due to the curse of dimensionality.
Ji Shi, Demetrio Labate
doaj +1 more source
Passage of fractal signals via circuit with a ferroelectric capacitor with a negative capacitance
The Journal of Engineering, 2019 In the report presented, the results of synthesis of two of the newest scientific areas, namely integrated ferroelectrics and fractal radio systems, have been shown on the simplest example.
Gadgymurad O. Abdullaev +4 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A Subclass of Meromorphic Multivalent Functions Generated by a Symmetric q-Difference Operator
MathematicsThis paper presents a novel symmetric q-analogue differential operator designed for meromorphic multivalent functions analytic in the punctured open unit disk.
Vasile-Aurel Caus
doaj +1 more source
The Journal of Engineering, 2019 The curtailment of wind power has caused huge economic losses and needs to be considered on the stage of transmission expansion planning (TEP). Based on the superquantile theory, the authors use the buffered failure probability to handle the events of ...
Dundun Liu +5 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source