Results 71 to 80 of about 159,150 (262)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Simplified LLR algorithm for m-QAM demodulation
The Journal of Engineering, 2019 Here, a simplified algorithm to calculate log-likelihood ratio (LLR) for m-QAM demodulation is proposed. Traditional method calculating LLR for m-QAM demodulation is supposed to do distance computing between any two constellation points so that the high ...
Xianle Cao, Yi Liu, Dongfang Hu
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Automated scheme for linearisation points selection in TPWL method applied to non-linear circuits
The Journal of Engineering, 2019 Trajectory piecewise linear (TPWL) approximation is a well-known model order reduction technique for non-linear systems. It involves weighted summation of the dimensionally reduced linear systems obtained at certain points on the system trajectory.
Shifali Kalra, Mashuq-un Nabi
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Distributed equalisation strategy for multi-battery energy storage systems
The Journal of Engineering, 2019 Multi-battery energy storage systems (MBESSs) are widely adopted to overcome the uncertainty problem of renewable energy sources. However, state-of-charge (SOC) imbalance issue of MBESSs brings great challenges to the optimal dispatching strategy and the
Feilong Fan +4 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Multiparameter extrapolation and deflation methods for solving equation systems
International Journal of Mathematics and Mathematical Sciences, 1984 Most models in economics and the applied sciences are solved by first order iterative techniques, usually those based on the Gauss-Seidel algorithm.
A. J. Hughes Hallett
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Sequential optimisation of orthogonal waveforms for MIMO radar
The Journal of Engineering, 2019 The existing methods to design orthogonal waveforms for multiple-input multiple-output radar mainly focus on the optimisation of autocorrelation and cross-correlation properties.
Zhongrui Huang, Bo Tang, Shuo Zhang
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