Results 71 to 80 of about 5,993,593 (296)

Approximation resistance on satisfiable instances for predicates with few accepting inputs

, 2014
For every integer k ≥ 3, we prove that there is a predicate P on k Boolean variables with (Formula Presented) accepting assignments that is approximation resistant even on satisfiable instances. That is, given a satisfiable CSP instance with constraint P,
Huang, Sangxia,, Sangxia Huang
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

On Topological Properties of IF Approximation Spaces

Fuzzy Information and Engineering, 2015
Rough approximation operators in approximation spaces are the core concept of rough set theory, which draw close links between rough set theory and topology.
Ning-Xin Xie
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Efficient approximation of random fields for numerical applications [PDF]

, 2014
This article is dedicated to the rapid computation of separable expansions for the approximation of random fields. We consider approaches based on techniques from the approximation of non-local operators on the one hand and based on the pivoted Cholesky ...
Michael Peters, Markus Siebenmorgen, Peters, Michael, Helmut Harbrecht, Siebenmorgen, Markus, Harbrecht, Helmut   +5 more
core   +1 more source

The mathematics of adversarial attacks in AI – why deep learning is unstable despite the existence of stable neural networks

European Journal of Applied Mathematics
The unprecedented success of deep learning (DL) makes it unchallenged when it comes to classification problems. However, it is well established that the current DL methodology produces universally unstable neural networks (NNs).
Alexander Bastounis, Anders Hansen, Verner Vlačić   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Approximation Theory XV: San Antonio 2016 [PDF]

, 2017
These proceedings are based on papers presented at the international conference Approximation Theory XV, which was held May 22–25, 2016 in San Antonio, Texas.
Santin, Gabriele, DE MARCHI, STEFANO, Idda, Andrea   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source