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The methods of pathos expression in patriotic songs [PDF]
SHS Web of Conferences, 2022 The article concerns the phenomenon of pathos, which is considered a category in rhetoric, and the methods of its expression in Chinese patriotic songs. There has been a specific kind of pathos in patriotic songs, a heroic one.
Kobzhitskaya Olga +2 more
doaj +1 more source
Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes
Journal of Clinical Oncology, 2021 PURPOSE Approximately 20% of patients with TP53-mutant myelodysplastic syndromes (MDS) achieve complete remission (CR) with hypomethylating agents. Eprenetapopt (APR-246) is a novel, first-in-class, small molecule that restores wild-type p53 functions in
D. Sallman +23 more
semanticscholar +1 more source
Cell Death and Differentiation, 2023 Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive functions. Therefore, compounds that can restore wt TP53 functions in mutant TP53
Zilu Wang +19 more
semanticscholar +1 more source
Asthma in developing countries in the Asia‐Pacific Region (APR)
Respirology (Carlton South. Print), 2023 There is growing interest in the epidemiology of asthma in developing countries, especially in the Asia‐Pacific Region (APR). A number of reviews have been published in this field, but a comprehensive synthesis of overall data has not been reported. Here,
D. Yasaratne, N. Idrose, S. Dharmage
semanticscholar +1 more source
APR-246 induces early cell death by ferroptosis in acute myeloid leukemia
Haematologica, 2021 APR-246 is a promising new therapeutic agent that targets p53 mutated proteins in myelodysplastic syndromes and in acute myeloid leukemia (AML). APR-246 reactivates the transcriptional activity of p53 mutants by facilitating their binding to DNA target ...
R. Birsen +15 more
semanticscholar +1 more source
GEOmedia, 2021 The challenge of measuring with constant accuracy, a changing and constantly evolving natural scenario, such as a sand mine can be. Quarzwerke Group, the company that owns the quarry, however, has clear ideas in this regard: rely on a partner, not only ...
Topcon Positioning Group
doaj +1 more source
APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy
Molecular Cancer Therapeutics, 2023 p53 mutation is common and highly related to radiotherapy resistance in rectal cancer. APR-246, as a small molecule, can restore the tumor-suppressor function to mutant p53.
Xuqin Xie +10 more
semanticscholar +1 more source
Chromium-Coated Zirconium Cladding Neutronics Impact for APR-1400 Reactor Core
Energies, 2022 The accident-tolerant fuel concept involves replacing the conventional cladding system (zirconium) with a new material or coating that has specific thermomechanical properties. The aim of this study is to evaluate the neutronics performance of a chromium
Mohammad Alrwashdeh, Saeed A. Alameri
semanticscholar +1 more source
Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246
British Journal of Cancer, 2022 Background p53 mutants contribute to the chronic inflammatory tumour microenvironment (TME). In this study, we address the mechanism of how p53 mutants lead to chronic inflammation in tumours and how to transform it to restore cancer immune surveillance.
Xiaolei Zhou +9 more
semanticscholar +1 more source
Neutronic Analysis of SiC/SiC Sandwich Cladding Design in APR-1400 under Normal Operation Conditions
Energies, 2022 Our aim is to study the neutronic behaviour of potential accident-tolerant fuel (ATF) claddings in a pressurised water reactor under normal operations. This work compares ATF silicon carbide composite (SiC/SiC) cladding to conventional ZIRLOTM cladding ...
Maithah Alaleeli +2 more
semanticscholar +1 more source