Results 51 to 60 of about 1,914,713 (386)

Realization of foreign-policy strategy of the United States of America is in countries of south-east Asia

open access: yesАмериканська історія і політика, 2016
The article attempts to analyze and consider implementation of foreign policy strategy of America on the Association of Southeast Asian Nations; highlights the geopolitical relations of the USA and ASEAN.
Inna Podbereznykh
doaj   +1 more source

Micronutrient intake status and associated factors in children aged 6–23 months in sub-Saharan Africa

open access: yesScientific Reports, 2023
Micronutrient deficiency has serious consequences across all ages worldwide, particularly in sub-Saharan Africa. Poor micronutrient (MN) consumption among children remains a major public health concern in many countries.
Melaku Tadege Engidaw   +7 more
doaj   +1 more source

PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies

open access: yesCancers, 2017
p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the ...
A. Perdrix   +6 more
semanticscholar   +1 more source

If Analytic Philosophy of Religion is Sick, Can It Be Cured? [PDF]

open access: yes, 2020
In this paper, I argue that, if ‘the overrepresentation of Christian theists in analytic philosophy of religion is unhealthy for the field, since they would be too much influenced by prior beliefs when evaluating religious arguments’ (De Cruz and De ...
Mizrahi, Moti
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Effect of Aromatic Petroleum Resin on Microstructure of SBS Modified Asphalt

open access: yesAdvances in Materials Science and Engineering, 2022
In this paper, aromatic petroleum resin (APR) was used as raw material. The fluorescence microscopic photography of styrene-butadiene-styrene block copolymer (SBS) modified asphalt with different contents of APR was carried out, and the effect of APR on ...
Hongjuan Wu   +3 more
doaj   +1 more source

Optimal financing and dividend distribution in a general diffusion model with regime switching [PDF]

open access: yes, 2015
We study the optimal financing and dividend distribution problem with restricted dividend rates in a diffusion type surplus model where the drift and volatility coefficients are general functions of the level of surplus and the external environment ...
Yang, Hailiang, Zhu, Jinxia
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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