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Aprepitant

Drugs, 2009
Aprepitant (Emend) is a neurokinin-1 (NK(1)) receptor antagonist that is able to alleviate the emetic effects of substance P. When combined with a standard regimen of a corticosteroid (dexamethasone) and a serotonin 5-HT(3) receptor antagonist (ondansetron), oral aprepitant (125 mg on day 1 then 80 mg once daily on days 2 and 3) was effective in the ...
Monique P, Curran, Dean M, Robinson
openaire   +2 more sources

Aprepitant: Review on Solubility Enhancement

Recent Advances in Drug Delivery and Formulation
Introduction: Substance P and its neurokinin (NK-1) receptors are upregulated in different pathophysiological conditions. Overexpression of the NK-1 receptor in cancer conditions has provided a promising pathway for cancer treatment. Clinically, Aprepitant (APT) is used as the only NK-1 antagonist in chemotherapy-induced nausea and vomiting (CINV ...
Lata, Kothapalli   +6 more
openaire   +2 more sources

Aprepitant

Drugs, 2012
Monique P Curran   +2 more
exaly   +2 more sources

Aprepitant as anticancer drug

2008
The present invention relates to the use of a heterocyclic compound according to generalstructural formula (I) for the treatment of cancer. In a preferred aspect the compound according 5to formula (I) is aprepitant.BACKGROUND OF THE INVENTIONCancer is a disorder in which a population of cells has become, in varying degrees, unresponsive 10to the ...
MICHAEL KHUN   +3 more
openaire   +1 more source

Aprepitant/ondansetron

Reactions Weekly, 2021
openaire   +1 more source

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