Results 1 to 10 of about 18,532 (197)
Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines [PDF]
Pharmacia, 2021 By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used
Yuliia Matiichuk +6 more
doaj +4 more sources
A Role for Janus Cyclohexyl Ring Motifs in Medicinal Chemistry. Incorporation Into G-Quadruplex Ligands and Anti-Trypanosoma brucei Activity. [PDF]
ChembiochemNaphthalene diimide (NDI) cores with peripheral fluorocyclohexyl ring systems are explored binding to G‐quadruplex DNA and were also assayed against the Trypanosoma brucei parasite. The most active compound of the series displayed nanomolar activity and suggested electrostatic interactions between the polarized cyclohexane and G‐Quad DNA.
Stewart JM +7 more
europepmc +2 more sources
Expanding Complex Morpholines Using Systematic Chemical Diversity. [PDF]
Org LettThe morpholine heterocycle is a structural unit found in many bioactive compounds and FDA-approved drugs, but the generation of more complex C-functionalized morpholine derivatives remains considerably underexplored.
Tang SA +9 more
europepmc +3 more sources
Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them. [PDF]
Medičnì Perspektivi, 2016 The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their harmful effects on human health.
S. V. Bіlous +3 more
doaj +2 more sources
Communications Chemistry, 2023 Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access.
Xing-Zi Li, Yu-Ping He, Hua Wu
doaj +1 more source
Morpholin-4-ium morpholine-4-carbodithioate [PDF]
Acta Crystallographica Section E Structure Reports Online, 2011 The title compound, C(4)H(10)NO(+)·C(5)H(8)NOS(2) (-), is built up of a morpholinium cation and a dithio-carbamate anion. In the crystal, two structurally independent formula units are linked via N-H⋯S hydrogen bonds, forming an inversion dimer, with graph-set motif R(4) (4)(12).
Ana C. Mafud +2 more
openaire +3 more sources
Flexible access to conformationally-locked bicyclic morpholines [PDF]
, 2013 A preparatively accessible route to a series of conformationally-locked bicyclic morpholines has been developed. This flexible approach allows for diversification in order for a small array of lead-like scaffolds to be synthesised from readily available ...
Lamont, Scott +5 more
core +4 more sources
Acta Chimica Slovenica, 2022 The studies on nitronaphthoquinone derivatives are rare in the literature, and the nitro group associated with the aromatic ring in the quinone system is known to increase the biological activity of naphthoquinone due to its electron-withdrawing ...
Aesha FSH Abdassalam +5 more
doaj +1 more source
Current Research in Toxicology, 2022 The cardiac embryonic stem cell test (ESTc) is a well-studied non-animal alternative test method based on cardiac cell differentiation inhibition as a measure for developmental toxicity of tested chemicals.
R.H. Mennen +5 more
doaj +1 more source
Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles [PDF]
, 2023 We report a heterocyclic merging approach to construct novel indazolo-piperazines and indazolo-morpholines. Starting from chiral diamines and amino alcohols, novel regiochemically (1,3 and 1,4) and stereochemically diverse (relative and absolute) cohorts
Viveki, Amol B +13 more
core +1 more source