Results 1 to 10 of about 89 (82)

Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines [PDF]

open access: yesPharmacia, 2021
By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used
Yuliia Matiichuk   +6 more
doaj   +3 more sources

Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them. [PDF]

open access: yesMedičnì Perspektivi, 2016
The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their harmful effects on human health.
S. V. Bіlous   +3 more
doaj   +2 more sources

Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons

open access: yesCommunications Chemistry, 2023
Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access.
Xing-Zi Li, Yu-Ping He, Hua Wu
doaj   +1 more source

Morpholin-4-ium morpholine-4-carbodithioate [PDF]

open access: yesActa Crystallographica Section E Structure Reports Online, 2011
The title compound, C(4)H(10)NO(+)·C(5)H(8)NOS(2) (-), is built up of a morpholinium cation and a dithio-carbamate anion. In the crystal, two structurally independent formula units are linked via N-H⋯S hydrogen bonds, forming an inversion dimer, with graph-set motif R(4) (4)(12).
Ana C. Mafud   +2 more
openaire   +3 more sources

Synthesis of New Regioisomers of 5-Nitro-1,4-Naphthoquinone, Evaluation of Antioxidant and Catalase Inhibition Activities

open access: yesActa Chimica Slovenica, 2022
The studies on nitronaphthoquinone derivatives are rare in the literature, and the nitro group associated with the aromatic ring in the quinone system is known to increase the biological activity of naphthoquinone due to its electron-withdrawing ...
Aesha FSH Abdassalam   +5 more
doaj   +1 more source

Genome-wide expression screening in the cardiac embryonic stem cell test shows additional differentiation routes that are regulated by morpholines and piperidines

open access: yesCurrent Research in Toxicology, 2022
The cardiac embryonic stem cell test (ESTc) is a well-studied non-animal alternative test method based on cardiac cell differentiation inhibition as a measure for developmental toxicity of tested chemicals.
R.H. Mennen   +5 more
doaj   +1 more source

Candidiasis and Mechanisms of Antifungal Resistance

open access: yesAntibiotics, 2020
Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which is caused by more than 20 types of Candida sp., with C. albicans being the most common.
Somanon Bhattacharya   +2 more
doaj   +1 more source

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. [PDF]

open access: yesPLoS Pathogens, 2010
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening ...
Shantelle L LaFayette   +7 more
doaj   +1 more source

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors

open access: yesMolecules, 2017
The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial activities of a new series of 2-(4 ...
Nafiz Öncü Can   +7 more
doaj   +1 more source

Application of the morpholines of 2 - [5 - (pyridin-4-yl) -1,2,4-triazol-3-ylthio] acetates for the treatment and prevention of some diseases

open access: yesZaporožskij Medicinskij Žurnal, 2014
Range of applications of morpholines of 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate for treatment and prevention of birds diseases is very wide.
I. V. Bushueva   +3 more
doaj   +1 more source

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