PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. [PDF]
PLoS Pathogens, 2010 Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening ...
Shantelle L LaFayette +7 more
doaj +1 more source
Yield and disease control in winter wheat in southern Sweden during 1977-2005 [PDF]
, 2009 Fungicides are routinely used to prevent yield losses in winter wheat in southern Sweden. Yield and 1000 grain weight (TGW) data from 432 trials in farmers’ fields were evaluated to review long-term yields (1977-2005) and control of eyespot and Leaf ...
Wiik, Lars
core +1 more source
Molecules, 2017 The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial activities of a new series of 2-(4 ...
Nafiz Öncü Can +7 more
doaj +1 more source
Synthesis of 6- and 7-Membered N-Heterocycles Using α-Phenylvinylsulfonium Salts [PDF]
, 2015 A concise synthesis of stereodefined C-substituted morpholines, piperazines, azepines, and oxazepines in moderate to excellent yields (27% to 75%) is reported by reaction of 1,2- or 1,3-amino alcohol/1,2- or 1,3-diamine with an α-phenylvinylsulfonium ...
Eoghan M. McGarrigle +7 more
core +2 more sources
Zaporožskij Medicinskij Žurnal, 2014 Range of applications of morpholines of 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate for treatment and prevention of birds diseases is very wide.
I. V. Bushueva +3 more
doaj +1 more source
Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification
Angewandte Chemie, EarlyView.Herein, we present a method for carbon isotope labeling of arylamides via the coupling of air‐stable palladium carboxamide complexes and boronic ester/acids. A wide variety of functionalized boronic esters and acids have been coupled with simple palladium carboxamides complexes.
Daniel V. Hoffmann +8 more
wiley +2 more sources
The Synthesis and Biological Activity of 1-Alkyl-4-(3-azacyclobenzoyl)-5-hydroxypyrazole Herbicides
CHIMIA, 2003 The benzoylpyrazoles belong to a class of herbicides that inhibit the enzyme 4-hydroxy-phenylpyruvate dioxygenase (HPPD). This mode of action is characterized by bleaching due to the disruption of plastoquinone and ?-tocopherol biosynthesis ...
Zoltan Benko +8 more
doaj +1 more source
Solvent-controlled selective transformation of 2-Bromomethyl-2-methylaziridines to functionalized Aziridines and Azetidines [PDF]
, 2012 The reactivity of 2-bromomethyl-2-methylaziridines toward oxygen, sulfur, and carbon nucleophiles in different solvent systems was investigated. Remarkably, the choice of the solvent has a profound influence on the reaction outcome, enabling the ...
Catak, Saron +7 more
core +1 more source
Selective Hydrogenation of Formamide to Methanol Over Supported Platinum Catalysts
Angewandte Chemie, EarlyView.Amine–CO2 adducts can be hydrogenated to formamides and subsequently to methanol under mild conditions (<150°C), establishing an integrated CO2 capture‐and‐conversion route in a heterogeneous system that directly links amine sorbent cycling with methanol synthesis.
Xuetao Qin +6 more
wiley +2 more sources
Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations
Angewandte Chemie, EarlyView.Mechanochemistry is redefining metal catalysis by controlling catalyst formulation, speciation, and deployment. This Review shows how milling, LAG, RAM, and TSE enable rapid metal‐complex assembly, distinctive catalytic manifolds, and scalable synthesis beyond solution chemistry.
Sourav Behera +2 more
wiley +2 more sources