Optimisation of a Key Cross-Coupling Reaction Towards the Synthesis of a Promising Antileishmanial Compound [PDF]
, 2019 During the course of a research program aimed at identifying novel antileishmanial compounds, a multi-gram synthesis of N-(trans-4-((4-methoxy-3-((R)-3-methylmorpholino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)-2-methylpropane-1-sulfonamide ((R)
Fra, Gloria +9 more
core +2 more sources
Dirhodium-catalyzed C-H arene amination using hydroxylamines [PDF]
, 2016 Primary and N-alkyl arylamine motifs are key functional groups in pharmaceuticals, agrochemicals, and functional materials, as well as in bioactive natural products. However, there is a dearth of generally applicable methods for the direct replacement of
Adebesin, Adeniyi Michael +6 more
core +1 more source
Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates [PDF]
, 2013 The present study was conducted to synthesize nitrogen containing derivatives of salicyl alcohol and to investigate in vivo their ulcerogenic potential in comparison with aspirin in rats.
Ali, Gowhar +6 more
core +1 more source
The European Zoological Journal, 2018 Two native species of the genus Cucujus show a wide geographic distribution in Europe, Cucujus cinnaberinus (Scopoli, 1763) and C. haematodes Erichson, 1845.
T. Bonacci +5 more
doaj +1 more source
Amine-Promoted Alkene Aziridination
, 2011 Aziridines, the smallest saturated aza-heterocycle, are not only prevalent in several natural products, but also represent a versatile synthetic tool for the chemist via exploitation of the strained ring system. Research described in this thesis concerns
Pullin, Robert David Charles +1 more
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Chronic morpholine exposure of rats
Fundamental and Applied Toxicology, 1989 The chronic toxicity and carcinogenic potential of morpholine were evaluated in 60 Sprague-Dawley rats/sex/group receiving morpholine at mean inhalation exposure concentrations of 0, 10, 50 and 150 ppm for 6 hr/day, 5 days/week, for 104 weeks. Survival, body weight gains, organ weights, hematology, and clinical chemistries were normal in exposed groups
Center for Environmental Toxicology, University of Florida, Alachua, Florida 32615 USA ( host institution ) +5 more
openaire +3 more sources
Biogeographical analysis within the family Phytoseiidae Berlese (Acari: Mesostigmata): an example from the large sub-genus Typhlodromus (Anthoseius) De Leon [PDF]
, 2011 Despite their great interest for pest management, the biogeography of the Phytoseiidae is still poorly known. This study focuses on the spatial distribution of one of the largest taxa within the family: the sub-genus Typhlodromus (Anthoseius) currently ...
Akashi Hernandes, Fabio +2 more
core +5 more sources
Зерновое хозяйство России, 2018 The article describes the laboratory experiments made to determine median toxic concentration (TC50) of fungicides taken from different chemical groups such as triazoles, strobilurins, morpholines and used both separately and in mixtures with fungicides ...
T. S. Kharlamova, V. I. Dolzhenko
doaj +2 more sources
Basal Stem Rot of Oil Palm : Screening System and Bioefficacy of Sterol Biosynthesis Inhibitors Against Ganoderma Boninense [PDF]
, 1996 Studies were designed to develop a practical, quick and reliable screening system for basal stem rot (BSR) disease of oil palm using rubber wood inoculum block as an infection foci. Inoculation was performed under non-sterile conditions.
Teh, Kim Sing
core
Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence [PDF]
, 2018 A modular and diastereodivergent synthesis of tetrahydro-1H-pyrrolo[1,2d]diazepine-(2,5)-diones is presented. The tetrahydropyrrolodiazepinedione scaffold is obtained via a base-mediated three-step isomerization/tandem cyclization of amino acid-coupled ...
Brown, Lauren E. +3 more
core +1 more source