Results 31 to 40 of about 18,532 (197)

New Strategy for the Synthesis of Substituted Morpholines

, 2016
A four-step synthesis of cis-3,5-disubstituted morpholines from enantiomerically pure amino alcohols is described. The key step in the synthesis is a Pd-catalyzed carboamination reaction between a substituted ethanolamine derivative and an aryl or ...
John P. Wolfe (1317546), Brandon R. Rosen (2195050), Matthew L. Leathen (2362492)   +2 more
core   +2 more sources

Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles

Advanced Science, EarlyView.
We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu, Youzhi Xu, Weitao Zhang, Yongyue Ning, Yaojia Jiang, Yongquan Ning, Genping Huang, Jiawei Cheng, Paramasivam Sivaguru, Xihe Bi   +9 more
wiley   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

Crystal Structure Prediction of Inorganic Materials: A Benchmark and Modern Evaluation

Advanced Intelligent Discovery, EarlyView.
Predicting a crystal’s structure from composition alone is a long‐standing challenge in materials discovery. The CSP180 benchmark of 180 inorganic crystals evaluates thirteen crystal structure prediction algorithms requiring no density functional theory (DFT) against DFT‐based baselines across twelve metrics.
Lai Wei, Sadman Sadeed Omee, Rongzhi Dong, Nihang Fu, Yuqi Song, Edirisuriya M. Dilanga Siriwardane, Meiling Xu, Ming Hu, Chris Wolverton, Jianjun Hu   +9 more
wiley   +1 more source

A paracetamol–morpholine adduct

Acta Crystallographica Section E Structure Reports Online, 2002
Paracetamol [also known as acet­amino­phen or N-(4-hydroxy­phenyl)­acet­amide] is an important analgesic drug that has recently been cocrystallized with a series of cyclic N- and O-donor compounds. This paper describes the formation of a paracetamol adduct with morpholine, viz. paracetamol–morpholine (1/2.5), C8H9NO2·2.5C4H9NO.
Oswald, I D H, Motherwell, W D S, Parsons, S, Pulham, C R   +3 more
openaire   +3 more sources

TOXICOLOGICAL ASSESSMENT OF FUNGICIDES FOR PATHOGENS OF PYRENOPHORA TRITICI-REPENTIS (DIED) IN WINTER WHEAT

Зерновое хозяйство России, 2018
The article describes the laboratory experiments made to determine median toxic concentration (TC50) of fungicides taken from different chemical groups such as triazoles, strobilurins, morpholines and used both separately and in mixtures with fungicides ...
T. S. Kharlamova, V. I. Dolzhenko
doaj   +2 more sources

Erweiterung der Peptidligation auf Saure pH‐Bereiche und Schnittstellen mit Glykosylierten und Phosphorylierten Aminosäuren

Angewandte Chemie, EarlyView.
Ein pyridinhaltiges Ligationsauxiliar beseitigt einen wesentlichen Engpass der Peptidligationschemie. Der für die Ligation nutzbare pH‐Bereich von 2,0–7,5 hilft, Epimerisierung zu vermeiden. Die native chemische Ligation (NCL) verläuft an praktisch jeder Ligationsstelle, einschließlich Reaktionen an β‐verzweigten sowie O‑glykosylierten oder O ...
Sebastian Trunschke, Antonia Feida, Hendrik Hanebrink, Arseniy Galashov, Alina Herfort, Oliver Seitz   +5 more
wiley   +1 more source

Synthesis of Enantiopure 3-Substituted Morpholines

, 2010
Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions ...
Kristensen, Jesper Langgaard, Jan Bornholdt, Felding, Jakob, Jakob Felding, Jesper Langgaard Kristensen, Bornholdt, Jan, Jesper Langgaard Kristensen (1743049), Jan Bornholdt (2254357), Jakob Felding (1378863)   +8 more
core   +2 more sources

Chronic morpholine exposure of rats

Fundamental and Applied Toxicology, 1989
The chronic toxicity and carcinogenic potential of morpholine were evaluated in 60 Sprague-Dawley rats/sex/group receiving morpholine at mean inhalation exposure concentrations of 0, 10, 50 and 150 ppm for 6 hr/day, 5 days/week, for 104 weeks. Survival, body weight gains, organ weights, hematology, and clinical chemistries were normal in exposed groups
Center for Environmental Toxicology, University of Florida, Alachua, Florida 32615 USA ( host institution ), Harbison, Raymond D., Marino, Dale J., Conaway, C.Clifford, Rubin, Lionel F., Gandy, Jay   +5 more
openaire   +3 more sources

Expedient and Rapid Synthesis of 1,2,3-Triazolo[5,1-c]morpholines through Palladium−Copper Catalysis

, 2016
A one-pot approach using palladium−copper as catalyst has been developed for the synthesis of morpholines fused with 1,2,3-triazole. Good regioselectivity, mild reaction conditions, high yields and short reaction time are the hallmarks of this ...
Bimolendu Das (803551), Sanjukta Mukherjee (2078500), Chinmay Chowdhury (445181), Basudeb Achari (1789177)   +3 more
core   +3 more sources