Results 51 to 60 of about 5,560 (153)

Mechanism Underlying Conflicting Drug-Drug Interaction Between Aprepitant and Voriconazole via Cytochrome P450 3A4-Mediated Metabolism.

Yonago acta medica
Background Voriconazole is an antifungal drug for which therapeutic monitoring is recommended to prevent side effects. Temporary administration of the antiemetic drug fosaprepitant remarkably decreases the plasma concentration of voriconazole from the ...
Masako Ishida, Takeshi Kumagai, Tatsuro Yamamoto, Hiroyuki Suzuki, Kuniaki Moriki, Masachika Fujiyoshi, Kiyoshi Nagata, Miki Shimada   +7 more
semanticscholar   +1 more source

Electroacupuncture for Managing Chemotherapy‐Induced Gastrointestinal Symptom Clusters in Patients With Breast Cancer: Study Protocol for a Randomized Controlled Trial

Health Care Science, Volume 5, Issue 1, Page 85-94, February 2026.
This multicenter randomized controlled trial evaluates electroacupuncture combined with standard antiemetics for managing chemotherapy‐induced gastrointestinal symptom clusters in patients with breast cancer. Integrated multi‐omics analyses aim to explore underlying mechanisms, offering potential non‐pharmacological strategies to enhance symptom ...
Xinlong Tao, Zhen Liu, Miaozhou Wang, Dengfeng Ren, Fuxing Zhao, Hongbin Wang, Guowang Yang, Ganlin Zhang, Zitao Li, Zhilin Liu, Shifen Huang, Yongzhi Chen, Mengting Da, Xiaoyan Ma, Hongxia Liang, Yongxin Li, Yinyin Ye, Yonghui Zheng, Xiao Liang, Guoshuang Shen, Xiaorong Bai, Jiuda Zhao   +21 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

A National Audit of Current UK Practice on the Use of Anti‐Emetics for Chemotherapy‐Induced Nausea and Vomiting in Children

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT This UK national audit aimed to assess adherence to evidence‐based chemotherapy‐induced nausea and vomiting (CINV) guidelines for children with cancer, which emphasise treatment emetogenicity assessment, symptom monitoring and appropriate antiemetic use.
Eloise Neumann, Thomas J. Jackson, Jessica E. Morgan, Robert Phillips, Jessica Bate, the CCLG Supportive Care Group   +5 more
wiley   +1 more source

Regularized Single‐Cell Imaging Enables Generalizable AI Models for Stain‐Free Cell Viability Screening

Small Methods, Volume 10, Issue 4, 23 February 2026.
Recent advances in AI suggest the potential for stain‐free cell viability screening on brightfield microscopy images. However, no model has been reliably generalized across previously unseen cell types and compounds. Here, we show that “regularized imaging” of single cells in nanowells enables training of generalizable AI models for stain‐free ...
Pan Deng, Deasung Jang, Samuel G. Berryman, Simon P. Duffy, Hongshen Ma   +4 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Aprepitant [PDF]

, 2020
openaire   +1 more source

Optimizing Antiemetic Strategies Across Phases of Chemotherapy-Induced Nausea and Vomiting: Real-World Evidence in Breast Cancer. [PDF]

Curr Oncol
Doğan A, Erölmez HN, Akdağ G, Yıldırım S, Sever ÖN.   +4 more
europepmc   +1 more source

Drug-assisted synthesis of copper nanoparticles and their induction of cuproptosis and necrosis for breast cancer therapy. [PDF]

J Zhejiang Univ Sci B
Wang Y, Gao J, Cheng Y, Pan H, Tang H, Liu C.   +5 more
europepmc   +1 more source

Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury. [PDF]

World J Hepatol
Kelleni MT, Abdelzaher WY, Adly M, Attya ME, Fawzy MA, Ibrahim MA.   +5 more
europepmc   +1 more source