Results 51 to 60 of about 8,326 (241)

Regularized Single‐Cell Imaging Enables Generalizable AI Models for Stain‐Free Cell Viability Screening

Small Methods, EarlyView.
Recent advances in AI suggest the potential for stain‐free cell viability screening on brightfield microscopy images. However, no model has been reliably generalized across previously unseen cell types and compounds. Here, we show that “regularized imaging” of single cells in nanowells enables training of generalizable AI models for stain‐free ...
Pan Deng, Deasung Jang, Samuel G. Berryman, Simon P. Duffy, Hongshen Ma   +4 more
wiley   +1 more source

Effects of Modification of Pain Protocol on Incidence of Post Operative Nausea and Vomiting. [PDF]

, 2016
BackgroundA Perioperative Surgical Home (PSH) care model applies a standardized multidisciplinary approach to patient care using evidence-based medicine to modify and improve protocols.
Ahn, Kyle, Bahn, Esther, Calderon, Michael-David, Harrington, Brian, Rinehart, Joseph B, Schwarzkopf, Ran, Sharfman, Zachary T, Snir, Nimrod   +7 more
core   +2 more sources

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Managing Skin Side Effects Associated With Oncology Treatments: Asian Perspective on Use of Dermocosmetics

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Skin adverse events (AEs) frequently accompany all types of anticancer treatments. This publication discusses how recent international guidance on best‐practices use of dermocosmetics can be adapted to the North Asia region (China, Hong Kong, Japan, Republic of Korea, and Taiwan).
Meng Pan, Jianguo Sun, Makoto Kawashima, You Chan Kim, Mison Chun, Chia‐Yu Chu, Yi‐Hsin Liang, Mee Chang, Delphine Kerob, Brigitte Dreno   +9 more
wiley   +1 more source

Enhanced anti-angiogenic effects of aprepitant-loaded nanoparticles in human umbilical vein endothelial cells

Scientific Reports
Recent advancements in cancer therapy have led to the development of novel nanoparticle-based drug delivery systems aimed at enhancing the efficacy of chemotherapeutic agents.
Elif Kaya-Tilki, Ahmet Alper Öztürk, Selin Engür-Öztürk, Miriş Dikmen   +3 more
doaj   +1 more source

Efficacy and Safety of Conventional and Biologic Therapies in Prurigo Nodularis: A Systematic Review and Meta‐Analysis

International Journal of Dermatology, EarlyView.
ABSTRACT Prurigo nodularis (PN) is a chronic, intensely pruritic skin disorder characterized by hyperkeratotic nodules and a debilitating itch–scratch cycle. Conventional therapies have limited efficacy and safety issues, while biologics have recently emerged as a promising alternative.
Andrea Lancz, Fanni Adél Meznerics, Renáta Árok, Anna Sára Lengyel, Bence Szabó, Péter Hegyi, Norbert Kiss, András Bánvölgyi   +7 more
wiley   +1 more source

Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis

Acta Dermato-Venereologica, 2017
Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus.
Louise Lönndahl, Mikael Holst, Maria Bradley, Hassan Killasli, Johan Heilborn, Martin A. Hall, Elvar Theodorsson, Jadwiga Holmberg, Klas Nordlind   +8 more
doaj   +1 more source

Effectiveness of Aprepitant in Patients with Refractory Pruritus Secondary to Sézary Syndrome [PDF]

, 2012
Background: In advanced stages, patients with Sézary Syndrome (SS) commonly report an ill-defined, severe and diffuse pruritus. Recently, it has been reported that Aprepitant, an oral neurokinin-1-receptor (NK1) antagonist, may have an important role in ...
Alves, R., Fernandes, I., Lima, M., Selores, M., Torres, T.   +4 more
core  

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review

International Journal of Dermatology, EarlyView.
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska, Isha Gandhi, Robert Adler, Deena Fayyad, Perya Bhagchandani, Shabnam Afzal, Waleed Adawi, Shivani Patel, Shawn G. Kwatra   +8 more
wiley   +1 more source

Addition of 3-day aprepitant to ondansetron and dexamethasone for prophylaxis of chemotherapy-induced nausea and vomiting among patients with diffuse large B cell lymphoma receiving 5-day cisplatin-based chemotherapy

Journal of the Egyptian National Cancer Institute, 2017
Background: Neurokinin-1 receptor antagonists, such as aprepitant are currently emerging as powerful prophylactic agents for chemotherapy-induced nausea and vomiting (CINV).
Raafat Abdel-Malek, Noha Abbas, Kyrillus S. Shohdy, Mohamed Ismail, Radwa Fawzy, Dalal S. Salem, Ezzat Safwat   +6 more
doaj   +1 more source