Results 61 to 70 of about 4,502 (202)

Cost-effectiveness of an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer in the UK

Cancer Management and Research, 2013
Samantha Humphreys,1 James Pellissier,2 Alison Jones3 1Market Access Department, Merck Sharp and Dohme Ltd, Hoddesdon, Hertfordshire, UK; 2Health Economic Statistics, Merck Research Laboratories, Upper Gwynedd, PA, USA; 3Department of Medical Oncology ...
Humphreys S, Pellissier J, Jones A
doaj  

The effect of aprepitant, a neurokinin-1 receptor antagonist, on epileptiform activity in the penicillin model of epilepsy

Medicine Science
Substance P (SP) is a peptide neurotransmitter that plays a role in pain transmission, stress, inflammation, and emesis through neurokinin-1 receptor (NK-1R).
Selma Cirrik, Eli̇f Dogan, Ali̇ Aslan, Ni̇yazi̇ Tasci   +3 more
doaj   +1 more source

Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage

Journal of Neuroinflammation, 2022
Background Pyroptosis is a programmed cell death mediated by inflammasomes. Previous studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted neuroprotection in several neurological diseases.
Peng Jin, Dongqing Qi, Yuhui Cui, Cameron Lenahan, John H. Zhang, Xiaogen Tao, Shuixiang Deng, Jiping Tang   +7 more
doaj   +1 more source

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy

MedComm, Volume 7, Issue 4, April 2026.
In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang, Zikai Dong, Yongfei Wang, Ziyi An, Siyuan Wang, Wei‐Lin Jin   +5 more
wiley   +1 more source

Peripheral Neuropathy in Non-Hodgkin’s Lymphoma Patients Receiving Vincristine with and Without Aprepitant/Fosaprepitant

, 2020
Background: Peripheral neuropathy is a common treatment-related adverse effect associated with vincristine. Vincristine is a major CYP3A4 substrate and is often administered alongside the neurokinin-1 (NK-1) receptor antagonists, aprepitant or ...
Edwards, Jessi K., Lewis, Paul O., Bossaer, John B., Sant, Ashley   +3 more
core   +1 more source

Aprepitant for the Treatment of Chronic Refractory Pruritus [PDF]

, 2017
Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life.
Shawn G. Kwatra, Jihad M. Alhariri, Alice He, Ronald J. Sweren, Madan M. Kwatra   +4 more
core   +1 more source

Aprepitant in the Treatment of Subacute Sclerosing Panencephalitis: A Randomized, Double-Blind, Placebo-Controlled Study

, 2020
Background: Aprepitant is a neurokinin-1 receptor antagonist approved for the treatment of chemotherapy-induced nausea. We aimed to investigate the safety and efficacy of aprepitant in patients with subacute sclerosing panencephalitis.
TEZCAN, SONGÜL, ARMAN KANDIRMAZ, EMİNE, SANCAR, MESUT   +2 more
core   +2 more sources

Clinical‐Pharmacological Drug Information Center of Hannover Medical School: Update From a Tertiary Care University Hospital (2022–2024)

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Drug information centers (DICs) are institutions dedicated to providing independent and up‐to‐date information on medications and their usage to healthcare professionals. Here, we provide an update from the clinical‐pharmacological DIC of Hannover Medical School, covering the period from April 2022 to December 2024.
Johannes Heck, Dirk O. Stichtenoth, Christoph Schröder, Ruxandra Sabau, Anna‐Leena K. Heim, Felix Koop, Thorben Pape, Sebastian Schröder, Martin Schulze Westhoff, Benjamin Krichevsky, Martin Klietz, Stephan Greten, Carsten Schumacher   +12 more
wiley   +1 more source

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Drug Design, Development and Therapy, 2020
Meng-Jie Yang, Hong-Rong Xu, Hui Li, Wei-Li Chen, Fei Yuan, Xue-Ning Li Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Xue-Ning LiDepartment of Clinical Pharmacology ...
Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN   +5 more
doaj  

Timing of Antidepressant Use Influences Long Term Functional Status in New Zealand Stroke Patients: A Retrospective Population Level Study

Journal of the Royal Society of New Zealand, Volume 56, Issue 2, April 2026.
This retrospective analysis explored the relationship between the timing of antidepressant use and long‐term functional status after stroke. We used linked health administrative data from a cohort of adult stroke patients in New Zealand. Demographics and prescription information were obtained from the National Minimum Dataset and Pharmaceutical ...
Shivankar Nair, Emma M. Tuckey, Deepak Gupta, Rong Liu, Alesha J. Smith, Ailsa L. McGregor   +5 more
wiley   +1 more source