Results 41 to 50 of about 3,594 (173)

Comparison of single-dose oral aprepitant and intravenous ondansetron for the prevention of post-operative nausea and vomiting in patients undergoing open abdominal surgery

Asian Journal of Medical Sciences
Background: Post-operative nausea and vomiting (PONV) remains one of the most common and distressing complications following general anesthesia, particularly after open abdominal surgery.
Mohd Rafiq Mir , Nowsheeba Rashid , Aaqib Suhail Mir , Waqrul Neesa   +3 more
doaj   +1 more source

Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis

Acta Dermato-Venereologica, 2017
Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus.
Louise Lönndahl, Mikael Holst, Maria Bradley, Hassan Killasli, Johan Heilborn, Martin A. Hall, Elvar Theodorsson, Jadwiga Holmberg, Klas Nordlind   +8 more
doaj   +1 more source

Review of nutrition management of pediatric intestinal pseudo‐obstruction

Nutrition in Clinical Practice, Volume 41, Issue 4, Page 1048-1060, August 2026.
Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman, Raisa Rani James, Bushra El‐Amaireh, Andrea Adler, Kadakkal Radhakrishnan, Sujithra Velayuthan   +5 more
wiley   +1 more source

Single center experience on efficacy and safety of Aprepitant for preventing chemotherapy-induced nausea and vomiting (CINV) in pediatric Hodgkin Lymphoma.

PLoS ONE, 2019
Chemotherapy-induced nausea and vomiting (CINV) is a distressing treatment side-effect that could negatively affect children's quality of life (QoL). Different scoring systems for CINV were applied and different antiemetic drugs were used; however, few ...
Giovanna Giagnuolo, Salvatore Buffardi, Francesca Rossi, Fara Petruzziello, Chiara Tortora, Isabella Buffardi, Nicoletta Marra, Giuliana Beneduce, Giuseppe Menna, Rosanna Parasole   +9 more
doaj   +1 more source

In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +1 more source

Intravenous aprepitant for prevention of postoperative nausea and vomiting in adults at moderate-to-high risk in China: a multicenter, randomized, double-blind, placebo-controlled trial

Anesthesiology and Perioperative Science
Purpose To evaluate whether peri-induction intravenous aprepitant 32mg/4.4ml improves the complete response (CR) to postoperative nausea and vomiting (PONV) within 24 h after surgery, as well as the 0–48 h net clinical effect, safety, and pharmacokinetic
Shichao Luo, Xiangqin Teng, YingYong Zhou, Qinghong Mao, Qingmei Zhang, Hong Luo, Liang Chen, Juan Wang, Hongmei Zhou, Jun Jing, Chuping Ye, Canlin Sun, Rui Zhan, Jinghua Ren, Chun Chen, Ping Qiang, Mingzhi Zheng, Wanyou Yu, Saiying Wang, Kaiming Duan   +19 more
doaj   +1 more source

Addition of 3-day aprepitant to ondansetron and dexamethasone for prophylaxis of chemotherapy-induced nausea and vomiting among patients with diffuse large B cell lymphoma receiving 5-day cisplatin-based chemotherapy

Journal of the Egyptian National Cancer Institute, 2017
Background: Neurokinin-1 receptor antagonists, such as aprepitant are currently emerging as powerful prophylactic agents for chemotherapy-induced nausea and vomiting (CINV).
Raafat Abdel-Malek, Noha Abbas, Kyrillus S. Shohdy, Mohamed Ismail, Radwa Fawzy, Dalal S. Salem, Ezzat Safwat   +6 more
doaj   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4246-4266, August 2026.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4592-4609, August 2026.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

Assessing the impact of aprepitant and ondansetron on postoperative nausea and vomiting in orthognathic surgeries: a randomized controlled trial

BMC Anesthesiology, 2023
Background Postoperative nausea and vomiting (PONV) is a common side effect associated with general anesthesia. Both ondansetron and aprepitant been effectively used to prevent PONV.
Mostafa Alam, Alireza Shakeri, Ardeshir Khorsand, Karim Nasseri, Sadaf Nasseri   +4 more
doaj   +1 more source