Results 41 to 50 of about 5,406 (200)

Neurokinin-1 inhibitors in the prevention of nausea and vomiting from highly emetogenic chemotherapy: a network meta-analysis

Therapeutic Advances in Medical Oncology, 2016
A network meta-analysis of the comparative effectiveness of neurokinin 1 (NK-1) inhibitors in the prophylaxis of highly emetogenic chemotherapy induced nausea and vomiting has been conducted.
Omar Abdel-Rahman
doaj   +1 more source

Evaluating Aprepitant single-dose plus granisetron and dexamethasone in children receiving highly emetogenic chemotherapy for the prevention of chemotherapy-induced nausea and vomiting: A triple-blinded randomized clinical trial

Hematology, Transfusion and Cell Therapy, 2023
Introduction: This study was performed to evaluate the degree of 3-day chemotherapy-induced nausea and vomiting (CINV) in children with cancer who received highly emetogenic chemotherapy (HEC) to ascertain the efficacy of aprepitant single-dose on dayL 1
Aziz Eghbali, Fatemeh Khazaei Kohpar, Kazem Ghaffari, Roghayeh Rahimi Afzal, Aygin Eghbali, Ali Ghasemi   +5 more
doaj   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment [PDF]

Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related nausea and vomiting, have demonstrated that pharmacological inhibition of NK1R effectively reduces the growth of several tumor types
Organero, Juan Ángel, Fernández, I., Moreno-Rodríguez, Nazaret, Khiar, Noureddine, Pozo, Esther, Pernia Leal, Manuel, Recio Jiménez, Rocío, Serrano, Rosario, Calero, Raúl, Fernández Fernández, Inmaculada, Lerena, Patricia, Valdivia Giménez, Victoria Esther, Moreno Rodríguez, Nazaret, Leal, Manuel Pernia, Pintado, Cristina, Valdivia, Victoria, Recio, Rocío   +16 more
core   +1 more source

Chemotherapy‐Induced Nausea and Vomiting in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy With Fluorouracil, Epirubicin, Cyclophosphamide Followed by Docetaxel Versus an Anthracycline‐Free Regimen With Docetaxel, Cyclophosphamide—Results From a Randomized Clinical Trial

International Journal of Cancer, Volume 159, Issue 8, Page 1990-2003, 15 October 2026.
Chemotherapy‐induced nausea and vomiting (CINV) remains a significant clinical problem despite modern antiemetics. In particular, antiemetic strategies for emerging cancer therapies lack detailed evaluation. This randomized trial analyzed hourly CINV data for patients with early breast cancer who received either docetaxel plus cyclophosphamide (TC) or ...
Manuel Hörner, Henning Schäffler, Lothar Häberle, Chloë Goossens, Kerstin Pfister, Elena Leinert, Kristina Veselinovic, Sara Y. Brucker, Uwe Köhler, Georg Heinrich, Andreas Schneeweiss, Matthias W. Beckmann, Peter A. Fasching, Wolfgang Janni, Brigitte Rack, Sabine Heublein, Philipp Ziegler   +16 more
wiley   +1 more source

Mean plasma concentration curves of oxycodone, noroxycodone, and oxymorphone in patients (n = 6) who were administered with 10 mg of CR oxycodone every 12 hours alone (period A, triangles) or with aprepitant (period B, squares).

, 2014
▴ without aprepitant, ▪ with aprepitant.
Masanori Toyoda (615518), Naomi Kiyota (562845), Yoshinori Imamura (615520), Takanobu Shimada (615519), Toru Mukohara (615521), Yutaka Fujiwara (615517), Naoko Chayahara (411772), Hironobu Minami (411771)   +7 more
core   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors

Molecules, 2020
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik, Piotr F. J. Lipiński, Joanna Matalińska, Przemysław Koźmiński, Aleksandra Misicka, Ewa Gniazdowska   +5 more
doaj   +1 more source

Comparison of single-dose oral aprepitant and intravenous ondansetron for the prevention of post-operative nausea and vomiting in patients undergoing open abdominal surgery

Asian Journal of Medical Sciences
Background: Post-operative nausea and vomiting (PONV) remains one of the most common and distressing complications following general anesthesia, particularly after open abdominal surgery.
Mohd Rafiq Mir , Nowsheeba Rashid , Aaqib Suhail Mir , Waqrul Neesa   +3 more
doaj   +1 more source