Results 21 to 30 of about 5,406 (200)

The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells

Biochemistry Research International, 2021
Introduction. Glioblastoma is the most malignant brain tumor with different therapeutic protocols, including surgery, radiotherapy, and chemotherapy. Substance P (SP), a peptide released by sensory nerves, increases cellular excitability by activating ...
Faranak Korfi, Hossein Javid, Reza Assaran Darban, Seyed Isaac Hashemy   +3 more
doaj   +1 more source

Aprepitant for Cough in Lung Cancer A Randomized Placebo-controlled Trial and Mechanistic Insights [PDF]

, 2020
Rationale: Effective cough treatments are a significant unmet need in patients with lung cancer. Aprepitant is a licensed treatment for nausea and vomiting, which blocks substance P activation of NK-1 (neurokinin 1) receptors, a mechanism also implicated
Yorke, J., Smith, Jaclyn A; id_orcid, Russell, P., Holt, Kimberley; id_orcid, Holt, Kimberley, Holt, K., Smith, J.A., Robinson, Ryan, Dockry, Rachel, Russell, Philip, Belvisi, Maria G, Yorke, Janelle, Blackhall, F., Dockry, Rachel; id_orcid, Smith, Jaclyn A, Birrell, Mark A, Robinson, R., Birrell, Mark A., Molasiotis, A., Blackhall, Fiona, Dockry, R., Belvisi, Maria G., Birrell, M.A., Molassiotis, Alex, Harle, A., Blackhall, Fiona; id_orcid, Belvisi, M.G., Harle, Amélie   +27 more
core   +1 more source

Effect of combinations of dexamethasone-ondansetron and dexamethasone-ondansetron-aprepitant versus aprepitant alone for early postoperative nausea and vomiting after day care gynaecological laparoscopy: A randomised clinical trial

Indian Journal of Anaesthesia, 2021
Background and Aims: This study was designed to compare the effectiveness of the combination of dexamethasone–ondansetron with oral aprepitant alone and triple combination therapy with all three agents (dexamethasone-ondansetron and oral aprepitant) in ...
Ingilala L Thanuja, Satyen Parida, Sandeep K Mishra, Ashok S Badhe   +3 more
doaj   +1 more source

Effects of aprepitant on post-operative nausea and vomiting in patients with congenital heart disease undergoing cardiac surgery or catheterization procedures: a retrospective study with subjects as their own historical control

Frontiers in Anesthesiology, 2023
IntroductionFor patients undergoing cardiac surgery and catheterization procedures, severe post-operative nausea and vomiting (PONV) can occur despite standard anti-emetic interventions.
John W. Belk, Mark D. Twite, Katherine S. Klockau, Lori J. Silveira, Rachel G. Clopton   +4 more
doaj   +1 more source

Aprepitant for the Prevention of Acute Chemotherapy-Induced Nausea and Vomiting in Children: Overcoming Barriers [PDF]

, 2018
Aprepitant is an effective antiemetic for the prevention of acute chemotherapy-induced nausea and vomiting (CINV) in children. This thesis presents an updated clinical practice guideline for the prevention of acute CINV that recommends children receiving
Patel, Priya
core   +1 more source

Population pharmacokinetic analysis reveals no impact of aprepitant on the pharmacokinetics of ifosfamide, 2-dechloroifosfamide, and 3-dechloroifosfamide

, 2023
International audienceSeveral case reports and retrospective series have clearly pointed to the role of aprepitant, an antiemetic drug, in the development of encephalopathy when used with ifosfamide.
Maud Toulmonde, Filleron, Thomas, Firmin, Nelly, Thomas Filleron, Chaltiel, Léonor, Lambert, Marie, Christine Chevreau, Chatelut, Étienne, Allal, Ben, Thibaud Valentin, Valentin, Thibaud, Yakoubi, Malika, Etienne Chatelut, Mseddi, Mourad, Chevreau, Christine, Marie Lambert, Mourad Mseddi, Toulmonde, Maud, Léonor Chaltiel, Nelly Firmin, Ben Allal, Malika Yakoubi   +21 more
core   +1 more source

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Nature Communications, 2019
The FDA approved drug aprepitant is an antagonist of the Neurokinin 1 receptor (NK1R). Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to gain further insights into the dynamics of aprepitant binding, which is ...
Shuanghong Chen, Mengjie Lu, Dongsheng Liu, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu, Kurt Wüthrich, Qiang Zhao   +14 more
doaj   +1 more source

The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein

Neurology Research International, 2021
Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the ...
Negeen Mehrabani, Mohammad Reza Vaezi Kakhki, Hossein Javid, Safieh Ebrahimi, Seyed Isaac Hashemy   +4 more
doaj   +1 more source

Cardioprotective action of aprepitant in a rat model of ischemia-reperfusioninduced myocardial injury: role of PI3K-AkT-GSK-3β-HIF-1α signaling pathway

Acta Cirúrgica Brasileira, 2022
Purpose: The present study explored the role and mechanism involved in aprepitant-induced cardioprotective effects in rat model of ischemia-reperfusion injury.
Mei Qian, Yang Liu
doaj   +1 more source

Utility of Aprepitant in the Management of Pediatric Patients with Cyclical Vomiting Syndrome

Medicines
Introduction: Cyclical vomiting syndrome (CVS) is a recurrent debilitating illness characterized by intense episodes of nausea and emesis with widely varied pharmacological management across the country.
Aravind Thavamani, Sindhoosha Malay, Jasmine Khatana, Sujithra Velayuthan, Senthilkumar Sankararaman   +4 more
doaj   +1 more source