Results 11 to 20 of about 3,594 (173)

Prediction of Moderate to Severe Delayed Chemotherapy‐Induced Nausea Using a Novel Algorithm Incorporating Individual Patient Factors [PDF]

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Purpose Chemotherapy‐induced vomiting and nausea (CINV) is difficult to accurately predict, especially in the delayed phase and can negatively affect a patient's' quality of life as well as reduce their motivation to continue lifesaving therapy.
Alisha P. Maity, Stephanie D. Kjelstrom, Kathryn J. Fleck, Erik L. Zeger, Zonera A. Ali, Arezoo Ghaneie, Aarti L. Shevade, Paul B. Gilman, Deric C. Savior, U. Margaretha Wallon   +9 more
wiley   +2 more sources

Aprepitant versus Olanzapine in Patients of Breast Cancer on Adriamycin and Cyclophosphamide Regimen – Role in Effectiveness of Prevention of Nausea and Vomiting [PDF]

Acta Medica Lituanica
Background: Chemotherapy-induced nausea and vomiting (CINV) is a significant concern for patients undergoing highly emetogenic chemotherapy (HEC). This study compares the efficacy of aprepitant and olanzapine in preventing CINV in breast cancer patients
Indrani Devi Sarma, Sukainnya Buragohain, Joonmoni Lahon, Indrani Bhagawati, Neelakshi Mahanta, Dibyajyoti Saikia   +5 more
doaj   +2 more sources

Enhanced efficacy of aprepitant-based triple prophylaxis in preventing postoperative nausea and vomiting following metabolic bariatric surgery: a single-center, retrospective cohort study [PDF]

Frontiers in Medicine
BackgroundMetabolic bariatric surgery (MBS) is associated with high risk of postoperative nausea and vomiting (PONV). We aimed to investigate the impact of aprepitant-based triple prophylaxis on PONV after MBS.MethodsWe reviewed a retrospective cohort of
Xiaodong Shan, Xiaodong Shan, Xiaodong Shan, Yidi Yang, Xiaoao Xiao, Mingchuang Zhang, Rui Chen, Qingqiu Huang, Yuanqing Gao, Xitai Sun, Xitai Sun   +10 more
doaj   +2 more sources

Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain

Frontiers in Pharmacology, 2022
Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely used to treat chemotherapy-induced nausea and vomiting.
Yang Yang, Wei Zhou, Xiuqi Xu, Xianxiu Ge, Fei Wang, Guang-Qin Zhang, Lin Miao, Xueting Deng   +7 more
doaj   +1 more source

The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells

Biochemistry Research International, 2021
Introduction. Glioblastoma is the most malignant brain tumor with different therapeutic protocols, including surgery, radiotherapy, and chemotherapy. Substance P (SP), a peptide released by sensory nerves, increases cellular excitability by activating ...
Faranak Korfi, Hossein Javid, Reza Assaran Darban, Seyed Isaac Hashemy   +3 more
doaj   +1 more source

Effects of aprepitant on post-operative nausea and vomiting in patients with congenital heart disease undergoing cardiac surgery or catheterization procedures: a retrospective study with subjects as their own historical control

Frontiers in Anesthesiology, 2023
IntroductionFor patients undergoing cardiac surgery and catheterization procedures, severe post-operative nausea and vomiting (PONV) can occur despite standard anti-emetic interventions.
John W. Belk, Mark D. Twite, Katherine S. Klockau, Lori J. Silveira, Rachel G. Clopton   +4 more
doaj   +1 more source

Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs

Virulence, 2020
With the rapid increase in the frequency of azole-resistant species, combination therapy appears to be a promising tool to augment the antifungal activity of azole drugs against resistant Candida species.
Hassan E. Eldesouky, Nadia A. Lanman, Tony R. Hazbun, Mohamed N. Seleem   +3 more
doaj   +1 more source

Effect of combinations of dexamethasone-ondansetron and dexamethasone-ondansetron-aprepitant versus aprepitant alone for early postoperative nausea and vomiting after day care gynaecological laparoscopy: A randomised clinical trial

Indian Journal of Anaesthesia, 2021
Background and Aims: This study was designed to compare the effectiveness of the combination of dexamethasone–ondansetron with oral aprepitant alone and triple combination therapy with all three agents (dexamethasone-ondansetron and oral aprepitant) in ...
Ingilala L Thanuja, Satyen Parida, Sandeep K Mishra, Ashok S Badhe   +3 more
doaj   +1 more source

Aprepitant [PDF]

pharma-kritik, 2004
In Kombination mit anderen hochwirksamen Antiemetika kann Aprepitant bei einer stark emetogenen Chemotherapie, besonders bei der Verabreichung von Cisplatin, Brechreiz und Erbrechen verhüten helfen.
openaire   +1 more source

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Nature Communications, 2019
The FDA approved drug aprepitant is an antagonist of the Neurokinin 1 receptor (NK1R). Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to gain further insights into the dynamics of aprepitant binding, which is ...
Shuanghong Chen, Mengjie Lu, Dongsheng Liu, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu, Kurt Wüthrich, Qiang Zhao   +14 more
doaj   +1 more source