Results 51 to 60 of about 3,594 (173)

Navigating the Post‐BCMA/GPRC5D Landscape: Efficacy of Selinexor, Bortezomib, and Dexamethasone After Sequential Immunotherapy Failure in Penta‐Refractory Multiple Myeloma—A Multicenter Analysis

American Journal of Hematology, Volume 101, Issue 7, Page 1433-1439, July 2026.
ABSTRACT Patients with relapsed/refractory multiple myeloma (RRMM) who are penta‐drug refractory, defined as resistant to two proteasome inhibitors, two immunomodulatory agents, and an anti‐CD38 monoclonal antibody, face a dismal prognosis, particularly after exposure to T‐cell–redirecting therapies.
Maximilian Al‐Bazaz, Winfried Alsdorf, Lisa Leypoldt, Piet Sonnemann, Christoph Schaefers, Jule Artzenroth, Marie Harzer, Abdulaziz Kamili, Leandra Bartke, Leon Cords, Jan Vorwerk, Theo Leitner, Markus Maulhardt, Kerstin Brinkert, Annamaria Brioli, Tim Richardson, Udo Holtick, Stefan M. Hillmann, Hans Salwender, Cyrus Khandanpour, Carsten Bokemeyer, Katja Weisel, Ricardo Kosch   +22 more
wiley   +1 more source

Cost-effectiveness of an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer in the UK

Cancer Management and Research, 2013
Samantha Humphreys,1 James Pellissier,2 Alison Jones3 1Market Access Department, Merck Sharp and Dohme Ltd, Hoddesdon, Hertfordshire, UK; 2Health Economic Statistics, Merck Research Laboratories, Upper Gwynedd, PA, USA; 3Department of Medical Oncology ...
Humphreys S, Pellissier J, Jones A
doaj  

Every‐other‐day palonosetron plus aprepitant for prevention of emesis following induction chemotherapy for acute myeloid leukemia: A randomized, controlled study from the “Rete Ematologica Pugliese”

Cancer Medicine, 2020
Background Compared with older 5‐HT3 receptor antagonists, palonosetron requires fewer drug administrations to prevent chemotherapy‐induced nausea and vomiting (CINV) following multiple‐day chemotherapy.
Nicola Di Renzo, Lorella Melillo, Fernando Porretto, Michela Dargenio, Vincenzo Pavone, Domenico Pastore, Patrizio Mazza, Donato Mannina, Anxur Merenda, Nicola Cascavilla, Giuseppina Greco, Rosella Matera, Erminio Bonizzoni, Luigi Celio, Maurizio Musso   +14 more
doaj   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Drug Design, Development and Therapy, 2020
Meng-Jie Yang, Hong-Rong Xu, Hui Li, Wei-Li Chen, Fei Yuan, Xue-Ning Li Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Xue-Ning LiDepartment of Clinical Pharmacology ...
Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN   +5 more
doaj  

Broadening the View: Substance P and Its Metabolism in Pruritus‐Related Diseases

The Journal of Dermatology, Volume 53, Issue 7, Page 967-979, July 2026.
ABSTRACT Chronic pruritus is a debilitating symptom accompanying numerous inflammatory skin diseases and remains a major therapeutic challenge. Neurogenic inflammation plays a central role in its pathogenesis, with the tachykinin substance P acting as a key mediator at the interface of the nervous system, immune cells, and cutaneous tissues.
Thomas Walter, Bjoern B. Burckhardt
wiley   +1 more source

The effect of aprepitant, a neurokinin-1 receptor antagonist, on epileptiform activity in the penicillin model of epilepsy

Medicine Science
Substance P (SP) is a peptide neurotransmitter that plays a role in pain transmission, stress, inflammation, and emesis through neurokinin-1 receptor (NK-1R).
Selma Cirrik, Eli̇f Dogan, Ali̇ Aslan, Ni̇yazi̇ Tasci   +3 more
doaj   +1 more source

Gastroenterological Society of Australia Position Statement on the Assessment and Management of Idiopathic Gastroparesis

Journal of Gastroenterology and Hepatology, Volume 41, Issue 7, Page 2043-2061, July 2026.
The first Australian guidance document on the assessment and management of idiopathic gastroparesis (IGP) reconceptualises IGP as a sensorimotor disorder. It proposes a novel multidisciplinary treatment algorithm and 20 high‐consensus recommendations, addressing common overlapping disorders, and providing clear guidance on associated disordered eating ...
Trina Kellar, Chamara Basnayake, Jessica Biesiekierski, Rebecca Burgell, Jessica Fitzpatrick, Geoffrey Hebbard, Vincent Ho, Hannah Kim, Simon R. Knowles, Christopher K. Rayner, May Wong, Nicholas J. Talley   +11 more
wiley   +1 more source

Histiocytic Sarcoma of Palatine Tonsil in a Pediatric Patient: A Case Report of a Rare and Aggressive Malignancy

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT A 7‐year‐old boy with a history of recurrent tonsillitis presented with progressive left‐sided throat pain, foreign body sensation, and cervical lymphadenopathy. During the examination, doctors found an ulcerated mass on the left palatine tonsil.
Ihsan ullah, Muhammad Sanaan Noor, Hammad Saif, Muhammad Maaz Bin Zahid, Muhammad Hassan Noor, Muhammad Asim Shah, Aizaz Anwar Khalid, Somaiya Ahmed   +7 more
wiley   +1 more source

Comparison of aprepitant versus ondansetron for prevention of postoperative nausea and vomiting: A systematic review and meta-analysis with trial sequential analysis

Indian Journal of Anaesthesia
Background and Aims: Postoperative nausea and vomiting (PONV) is a common complication after surgery. Preventing PONV in high-risk patients often requires a multimodal approach combining antiemetic drugs with diverse mechanisms.
Madhusudan P. Singh, Meenalotchini P. Gurunthalingam, Ayushee Gupta, Juhi Singh   +3 more
doaj   +1 more source