Results 81 to 90 of about 5,406 (200)

Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU)

Acta Dermato-Venereologica, 2019
The aim of this multicentre, randomized, double-blind, placebo-controlled, cross-over, phase-II study was to determine the antipruritic effect of aprepitant vs.
Athanasios Tsianakas, Claudia Zeidler, Claudia Riepe, Matthias Borowski, Caroline Forner, Joachim Gerss, Martin Metz, Petra Staubach, Ulrike Raap, Martin Kaatz, Marc Urban, Thomas A. Luger, Sonja Ständer   +12 more
doaj   +1 more source

Aprepitant loaded solid preconcentrated microemulsion for enhanced bioavailability: A comparison with micronized Aprepitant

European Journal of Pharmaceutical Sciences, 2015
Aprepitant (APT) is a lipophilic, poorly water soluble drug with moderate permeability characteristic. Therefore, we aimed to improve solubility as well as permeability that could possibly improve oral bioavailability of APT. For this purpose, Quality by design (QbD) approach employing simplex lattice mixture design was used to prepare solid ...
Sunil, Kamboj, Radhika, Sharma, Kuldeep, Singh, Vikas, Rana   +3 more
openaire   +2 more sources

Cost‐effectiveness analysis of aprepitant‐based anti‐emetic regimen for children receiving highly emetogenic chemotherapy: Individual patient data analysis of a randomized trial

, 2022
Background Aprepitant has been shown to reduce chemotherapy-induced nausea and vomiting in children receiving highly emetogenic chemotherapy (HEC).
Sharma, Priya, Manraj Singh Sra, Giri, Rupak Kumar, Bakhshi, Sameer, Shuvadeep Ganguly, Archana Sasi, Ganguly, Shuvadeep, Sameer Bakhshi, Azgar Abdul Rasheed, Sasi, Archana, Rupak Kumar Giri, Rasheed, Azgar Abdul, Priya Sharma, Sra, Manraj Singh   +13 more
core   +1 more source

Cytotoxic and apoptotic effects of neurokinin-1 receptor (NK1R) antagonist on multiple myeloma cells [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2019
Background and Aim: Despite therapeutic improvements in recent decades, multiple myeloma (MM) still remains as one of the leading causes of death all over the world. Previous studies have indicated role of neurokinin-1 receptor (NK1R) in the pathogenesis
Elham Razani, Davood Bashash
doaj   +1 more source

Aprepitant exposure and long-term prognosis in breast cancer: a propensity-score-matched cohort study

European Journal of Medical Research
Background Whether the neurokinin-1 receptor (TACR1) antagonist aprepitant confers oncologic benefit beyond antiemesis remains uncertain. We evaluated the association between aprepitant exposure during adjuvant chemotherapy and long-term outcomes in ...
Limin Pan, Zhiyuan Zhang, Wanyue Li, Feng Lv, Yuanxiang Lu, Yimin Liu   +5 more
doaj   +1 more source

In-vitro und in-vivo Untersuchungen mit dem Antiemetikum Aprepitant [PDF]

, 2008
Aprepitant, ein Neurokinin-1-Rezeptorantagonist, wird zur Therapie des Zytostatika induzierten Erbrechen eingesetzt. Besonders hohe Wirksamkeit erzielt man gegen die verzögerte Emesis.
von Aretin, Marie-Bernadette
core  

Aprepitant versus Olanzapine in Patients of Breast Cancer on Adriamycin and Cyclophosphamide Regimen – Role in Effectiveness of Prevention of Nausea and Vomiting

Acta Medica Lituanica
Background: Chemotherapy-induced nausea and vomiting (CINV) is a significant concern for patients undergoing highly emetogenic chemotherapy (HEC). This study compares the efficacy of aprepitant and olanzapine in preventing CINV in breast cancer patients
Indrani Devi Sarma, Sukainnya Buragohain, Joonmoni Lahon, Indrani Bhagawati, Neelakshi Mahanta, Dibyajyoti Saikia   +5 more
doaj   +1 more source

The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages

Drug Design, Development and Therapy, 2020
Xiao-nan Zhao,* Zhen-zi Bai,* Cheng-hua Li, Chuan-lun Sheng, Hong-yan Li Department of Infectious, The Third Hospital of Jilin University, Changchun City, Jilin Province 130033, People’s Republic of China*These authors contributed equally to this ...
Zhao X, Bai Z, Li C, Sheng C, Li H
doaj  

The Neurokinin-1 Receptor Antagonist Aprepitant, a New Drug for the Treatment of Hematological Malignancies: Focus on Acute Myeloid Leukemia

, 2020
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. To treat the disease successfully, new therapeutic strategies are urgently needed.
Rafael Coveñas, Miguel Muñoz, Coveñas, Rafael, Muñoz, Miguel   +3 more
core   +1 more source

Mechanism Underlying Conflicting Drug-Drug Interaction Between Aprepitant and Voriconazole via Cytochrome P450 3A4-Mediated Metabolism [PDF]

Background: Voriconazole is an antifungal drug for which therapeutic monitoring is recommended to prevent side effects. Temporary administration of the antiemetic drug fosaprepitant remarkably decreases the plasma concentration of voriconazole from the ...
Fujiyoshi,Masachika, Ishida,Masako, シマダ,ミキエ, Nagata,Kiyoshi, 島田,美樹, Kumagai,Takeshi, Suzuki,Hiroyuki, 100001255, Yamamoto,Tatsuro, Moriki,Kuniaki, Shimada,Miki, 10196488, 4867   +12 more
core   +1 more source