Results 81 to 90 of about 4,502 (202)

The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?

open access: yes, 2020
Neurokinin-1 receptor (NK-1R) antagonists exert antitumor action, are safe and do not cause serious side-effects. These antagonists (via the NK-1R) exert multiple actions against cancer: antiproliferative and anti-Warburg effects and apoptotic, anti ...
Rafael Coveñas   +3 more
core   +1 more source

Cytotoxic and apoptotic effects of neurokinin-1 receptor (NK1R) antagonist on multiple myeloma cells [PDF]

open access: yesمجله علمی دانشگاه علوم پزشکی کردستان, 2019
Background and Aim: Despite therapeutic improvements in recent decades, multiple myeloma (MM) still remains as one of the leading causes of death all over the world. Previous studies have indicated role of neurokinin-1 receptor (NK1R) in the pathogenesis
Elham Razani, Davood Bashash
doaj   +1 more source

The interaction of ifosfamide and aprepitant in gynecologic malignancies

open access: yesGynecologic Oncology Case Reports, 2013
•Aprepitant combined with ifosfamide may lead to encephalopathy.•Aprepitant-ifosfamide induced encephalopathy was of short duration in these cases.
Shindorf, Mackenzie L.   +2 more
openaire   +2 more sources

Aprepitant en el tratamiento de náusea y vómito inducidos por quimioterapia altamente emetogénica [PDF]

open access: yes, 2012
Se estudian 23 pacientes oncológicos, para comprobar la eficacia del "Aprepitant" encontrol de emesis provocada por administración de quimioterapia altamente emetogénica.
Duque Espinoza, Sandra   +1 more
core  

Mechanism Underlying Conflicting Drug-Drug Interaction Between Aprepitant and Voriconazole via Cytochrome P450 3A4-Mediated Metabolism [PDF]

open access: yes
Background: Voriconazole is an antifungal drug for which therapeutic monitoring is recommended to prevent side effects. Temporary administration of the antiemetic drug fosaprepitant remarkably decreases the plasma concentration of voriconazole from the ...
Fujiyoshi,Masachika   +12 more
core   +1 more source

The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages

open access: yesDrug Design, Development and Therapy, 2020
Xiao-nan Zhao,* Zhen-zi Bai,* Cheng-hua Li, Chuan-lun Sheng, Hong-yan Li Department of Infectious, The Third Hospital of Jilin University, Changchun City, Jilin Province 130033, People’s Republic of China*These authors contributed equally to this ...
Zhao X, Bai Z, Li C, Sheng C, Li H
doaj  

Drug-drug interactions with aprepitant in antiemetic prophylaxis for chemotherapy

open access: yes, 2018
In the current guidelines to prevent hemotherapyinduced nausea and vomiting, multiple antiemetic drugs are administered simultaneously. In patients who receive highly emetogenic chemotherapy, aprepitant, an NK1-receptor antagonist, is combined with ...
Hoeven, J.J.M. van der   +5 more
core  

Retrospective safety evaluation of aprepitant in pediatric patients receiving vincristine or doxorubicin: a feasibility study

open access: yes, 2022
Pharmacy residents have the opportunity to complete a research project during their residency training, which provides them with skills on how to conduct and manage a research project.
Koo, Alicia   +5 more
core  

Relative Bioavailability of an Extemporaneous Oral Suspension of Aprepitant in Healthy Adult Volunteers

open access: yes, 2018
Pharmacy residents have the opportunity to complete a research project during their residency training, which provides them with skills on how to conduct and manage a research project.
Walker, Scott   +5 more
core   +1 more source

In-vitro und in-vivo Untersuchungen mit dem Antiemetikum Aprepitant

open access: yes, 2008
Aprepitant, ein Neurokinin-1-Rezeptorantagonist, wird zur Therapie des Zytostatika induzierten Erbrechen eingesetzt. Besonders hohe Wirksamkeit erzielt man gegen die verzögerte Emesis.
von Aretin, Marie-Bernadette
core  

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