Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs [PDF]
, 2017 Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers. Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro ...
Dunn, Claire +4 more
core +1 more source
Gastric myoelectric activity during cisplatin-induced acute and delayed emesis reveals a temporal impairment of slow waves in ferrets: effects not reversed by the GLP-1 receptor antagonist, exendin (9-39). [PDF]
, 2017 Preclinical studies show that the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin (9-39), can reduce acute emesis induced by cisplatin. In the present study, we investigate the effect of exendin (9-39) (100 nmol/24 h, i.c.v), on cisplatin (5
Aggarwal +74 more
core +1 more source
مقايسه ميزان بروز تهوع و استفراغ بعد از عمل جراحی استرابيسم دراستفاده از ماسک راه هوايی حنجره ای و انتوباسيون تراشه [PDF]
, 2014 تهوع و استفراغ بعد از عمل جراحی عارضه نسبتاّ شايعی است که باعث ناخوشنودی بيمار، افزايش زمان بستری و افزايش هزينهها و در موارد شديد باعث دهيدراتاسيون، اختلال الکتروليتی، آسپيراسيون، پنومونی و حتی باز شدن بخيه های محل جراحی ميشود.
ایزانلو, عذرا +4 more
core
Medical Countermeasures for Radiation Induced Health Effects: Reports of an Interagency Panel Session Held at the NASA Human Research Program Investigator's Workshop, January 26, 2017 [PDF]
An Interagency Panel Session organized by the NASA Human Research Program Space Radiation Program Element (SRPE) was held during the NASA Human Research Program (HRP) Investigators Workshop (IWS) in Galveston, Texas on January 26, 2017 to identify ...
Carnell, Lisa S. +8 more
core +1 more source
, 2014 O Prurido crónico é um sintoma que tem um impacto significativo na qualidade de vida dos doentes. Pode estar associado a um vasto conjunto de doenças e na maioria dos casos, é difícil conseguir um alívio completo da sintomatologia. A investigação da sua
Amaro, C, Brás, S, Cardoso, J
core
Emerging Role of Aprepitant in Cannabis Hyperemesis Syndrome [PDF]
, 2019 Swetha Parvataneni +3 more
openalex +1 more source
Antitumor Strategies Targeting Peptidergic Systems
EncyclopediaPeptidergic systems show promise as targets for fighting tumors. While some peptides encourage the growth and spread of tumor cells and angiogenic mechanisms, others display antitumor properties. As such, peptide ligands and receptor antagonists could be
Francisco D. Rodríguez, Rafael Coveñas
doaj +1 more source
RECHALLENGE WITH ANTI-EGFR MONOCLONAL ANTIBODIES IN PRETREATED METASTATIC COLORECTAL CANCER PATIENTS: BEYOND THE LIMITS OF ACQUIRED RESISTANCE [PDF]
, 2012 Background: Scientific data provide today the evidence that secondary K-RAS mutations do not occur during anti-EGFR therapy in CRC patients. This multicenter phase II prospective study aims to investigate the activity of a retreatment with a cetuximab ...
BRONTE, Giuseppe
core
Chemotherapy against human African trypanosomiasis: Is there a road to success? [PDF]
, 2017 For over fifty years, human African trypanosomiasis (HAT, sleeping sickness) has been treated with suramin, pentamidine and the very toxic organo-arsenical melarsoprol that was the only drug available for effective treatment of the second stage of the ...
BURRI, CHRISTIAN
core