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Aprotinin, a carbohydrate-binding protein [PDF]
Histochemie, 1973 Evidence is presented for a carbohydrate-binding property of aprotinin, which is preserved both in a fluorescein isothiocyanate (FITC) conjugate and a cyanogen bromidelinked Sepharose conjugate of the protein. Both conjugates similarly retain their tryptic and chymotryptic inhibitory properties.
John A. Kiernan, R. W. Stoddart
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The Annals of Thoracic Surgery, 1993
Aprotinin is a nonspecific serine protease inhibitor extracted from bovine lung. It was first used during cardiopulmonary bypass to inhibit plasmin-induced complement activation. By chance significant reductions of blood loss and blood requirements were noted in treated patients.
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Aprotinin is a nonspecific serine protease inhibitor extracted from bovine lung. It was first used during cardiopulmonary bypass to inhibit plasmin-induced complement activation. By chance significant reductions of blood loss and blood requirements were noted in treated patients.
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Aprotinin does not prolong the Sonoclot aprotinin-insensitive activated clotting time [PDF]
Journal of Clinical Anesthesia, 2007 To determine whether a new Sonoclot-based, aprotinin-insensitive activated clotting time (aiACT) assay yields stable results over a broad range of aprotinin concentrations.Prospective trial conducted on in vitro blood samples.Tertiary-care teaching medical center.19 healthy adult volunteers.Whole blood samples were collected from volunteers. Heparin (2
William C. Oliver +4 more
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Aprotinin and Anaphylaxis: Analysis of 12,403 Exposures to Aprotinin in Cardiac Surgery
The Annals of Thoracic Surgery, 2007Hypersensitivity reactions to the nonspecific proteinase inhibitor aprotinin may occur. The present study evaluates the incidence of hypersensitivity reactions to aprotinin.Data were prospectively collected as part of the institution's quality assurance program.
Anna-Laure Boulesteix +3 more
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1991
Monitoring of the adequacy of anticoagulation is essential to the safe conduct of cardiopulmonary bypass (CPB). While there is no universally accepted heparin level or test of adequate anticoagulation during cardio-pulmonary bypass, the automated activated clotting time (Hemochron ACT) became the routine method of monitoring heparinization in most ...
H. Kiefer +3 more
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Monitoring of the adequacy of anticoagulation is essential to the safe conduct of cardiopulmonary bypass (CPB). While there is no universally accepted heparin level or test of adequate anticoagulation during cardio-pulmonary bypass, the automated activated clotting time (Hemochron ACT) became the routine method of monitoring heparinization in most ...
H. Kiefer +3 more
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Current Opinion in Anaesthesiology, 2009
The nonspecific protease inhibitor aprotinin has been used successfully to reduce bleeding in cardiac surgery. Recent investigations have questioned its safety, and aprotinin has finally been withdrawn from marketing after a large prospective study demonstrated a trend toward higher mortality.The initial studies of Karkouti and Mangano provoked a ...
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The nonspecific protease inhibitor aprotinin has been used successfully to reduce bleeding in cardiac surgery. Recent investigations have questioned its safety, and aprotinin has finally been withdrawn from marketing after a large prospective study demonstrated a trend toward higher mortality.The initial studies of Karkouti and Mangano provoked a ...
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Aprotinin binding to amyloid fibrils [PDF]
European Journal of Biochemistry, 2000 Different low molecular mass ligands have been used to identify amyloid deposits. Among these markers, the dyes Thioflavin T and Congo Red interact specifically with the β‐sheet structure arranged in a cross‐β conformation, which is characteristic of amyloid. However, the molecular details of this interaction remain unknown.
Pedro Pereira +4 more
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Aprotinin—Are There Lessons Learned?
JAMA, 2007THIS PAST YEAR HAS BEEN A COMPLICATED ONE FOR aprotinin, an antifibrinolytic serine protease inhibitor used to lessen bleeding in patients undergoing cardiac surgery with cardiopulmonary bypass. Thirteen years after the initial approval of aprotinin by the US Food and Drug Administration, the report by Mangano and colleagues in this issue of JAMA will ...
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Topical aprotinin in cardiac operations
The Annals of Thoracic Surgery, 1994We performed a prospective, randomized, double-blind trial of topical aprotinin versus placebo in 100 patients undergoing cardiac operations with cardiopulmonary bypass. Fifty-five patients received aprotinin. Forty underwent coronary artery bypass grafting (CABG) and 15 valve replacement +/- CABG.
Nick Giannopoulos +6 more
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Antiinflammatory Effects of Aprotinin
Transfusion Alternatives in Transfusion Medicine, 2004SUMMARYAprotinin is a serine protease inhibitor that binds to human serine proteases with various affinities. This small protein has profound effects on the systemic inflammatory response syndrome induced by cardiopulmonary bypass. The intersecting pathways of complement, cytokines, coagulation, fibrinolytic, and kinin‐kallikrein systems all converge ...
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