Results 221 to 230 of about 45,024 (296)

Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early‐Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized‐Controlled Trials

open access: yesClinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Early‐phase clinical trials focus heavily on demonstrating safety and tolerability of drug candidates. Clinical laboratory test results outside of reference intervals (RIs) are often interpreted as possible indicators of harm. However, values outside RIs do not necessarily constitute drug‐induced adverse effects.
Jannik Rousel   +6 more
wiley   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

open access: yesInternational Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova   +2 more
wiley   +1 more source

Myeloid Cell Function and Cytokine Profiles in Paediatric Haemophilia A: Insights From FVIII and Emicizumab Prophylaxis

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Haemophilia A (HA) is an X‐linked bleeding disorder caused by factor VIII (FVIII) deficiency, treated with FVIII infusions or, more recently, Emicizumab subcutaneously. Although Emicizumab is safe and effective, FVIII is still required for severe bleeding, trauma, or surgery, and few studies have compared these prophylactic options in ...
Alessia Cottonaro   +10 more
wiley   +1 more source

Supraumbillical Skin Retraction After Laser Assisted Liposuction/Lipolysis

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Supraumbilical skin laxity is a major surgical challenge. A literature review on laser‐assisted liposuction/lipolysis (LAL/L) speaks in favor of skin tightening. Alternative methods include visible postoperative scar. Aims The aim is to determine the vertical retraction of the supraumbilical skin and its association with age, gender,
Ivonne Žgaljardić   +7 more
wiley   +1 more source

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