Results 251 to 260 of about 45,024 (296)

The investigation of a prolonged APTT with specific clotting factor assays is unnecessary if an APTT with Actin FS is normal

International Journal of Laboratory Hematology, 2011
An isolated prolongation to the activated partial thromboplastin time (APTT) can be caused by the presence of the lupus anticoagulant or an intrinsic or contact factor deficiency, of which only deficiencies of factors VIII, IX or XI are associated with bleeding. Our local protocol states that further investigation of a prolonged APTT by specific assays
Annette Bowyer, Steve Kitchen, M Makris   +2 more
exaly   +2 more sources

Monitoring of Unfractionated Heparin Therapy in the Intensive Care Unit Using a Point-of-Care aPTT: A Comparative, Longitudinal Observational Study with Laboratory-Based aPTT and Anti-Xa Activity Measurement

Journal of Clinical Medicine, 2022
: Continuous intravenous unfractionated heparin (UFH) is administered routinely in the intensive care unit (ICU) for the anticoagulation of patients, and monitoring is performed by the activated partial thromboplastin time (APTT) or anti-Xa activity ...
Benjamin Lardinois, Michael Hardy, Isabelle Michaux   +2 more
exaly   +2 more sources

Monitoring heparin treatment with the APTT: the effect of methodological changes on the APTT

The Netherlands Journal of Medicine, 1996
To assess the effect on the desired activated partial thromboplastin time (APTT) of altered practice in the laboratory control of heparin treatment.Descriptive study of the number of APTTs in the desired range (DR) in 1987 (historical controls) and in 1992/1993.
J W, Krulder, F J, van der Meer, E, Briët, A E, Meinders   +3 more
openaire   +2 more sources

The Measurement of Heparin by the APTT

Thrombosis and Haemostasis, 1979
In a previous international collaborative survey*, it was shown that some commercial PTT reagents and techniques were unsuitable for measuring the anticoagulant effect of heparin. In vitro studies, with a variety of commercial heparins further supports this finding.
L. Poller, Jean M. Thomson, D. J. Fletcher   +2 more
openaire   +1 more source

Variability in Heparin Sensitivity of APTT Reagents

American Journal of Clinical Pathology, 1986
Activated partial thromboplastin time (APTT) is the most widely used coagulation test for monitoring heparin therapy. This study quantitates the differences in heparin sensitivity of seven commercially available APTT reagents, using plasma samples obtained from 20 subjects. The reagents studied were Actin, Actin FS, Automated APTT, Cephotest, Coagachek
T D, Bjornsson, P V, Nash
openaire   +2 more sources

Determination of APTT factor sensitivity – the misguiding guideline [PDF]

International Journal of Laboratory Hematology, 2013
INTRODUCTION: The Clinical and Laboratory Standards Institute (CLSI) has produced a guideline detailing how to determine the activated partial thromboplastin time's (APTT) sensitivity to clotting factor deficiencies, by mixing normal and deficient ...
A S Lawrie, Steve Kitchen, Maria Efthymiou   +2 more
exaly   +1 more source

STANDARDIZATION OF THE APTT TEST CURRENT STATUS

Scandinavian Journal of Haematology, 1980
The partial thromboplastin time (PTT) which is used as an overall measure of the intrinsic clotting system, is the commonest coagulation test employed in routine laboratories apart from the prothrombin time. The main functions of the test are: 1. to screen intrinsic coagulation defects; 2. to control heparin administration; 3.
openaire   +2 more sources

Performance characteristics of a new synthetic APTT reagent

Clinical & Laboratory Haematology, 1998
Performance characteristics of a totally synthetic activated partial thromboplastin time (APTT) reagent, recently available commercially, were evaluated and compared with a rabbit-brain extracted reagent. We found that the synthetic reagent, Synthasil, returned significantly higher normal APTT values than the brain-extracted reagent, Thrombosil.
C, Ts'ao, D, Neofotistos, M, Oropeza, M, Rogan, M, Santos   +4 more
openaire   +2 more sources

To aPTT or not to aPTT: Evaluating the optimal monitoring strategy for unfractionated heparin

Thrombosis Research, 2022
Nathan T, Connell, Katelyn W, Sylvester
openaire   +2 more sources

Comparison of Two APTT Methods of Monitoring Heparin Therapy: APTT Ratio and Heparin Response of Pooled Normal Plasma

American Journal of Clinical Pathology, 1990
The sensitivity of the reagents for activated partial thromboplastin time (APTT) test varies greatly. Consequently the physicians who prescribe heparin based on certain APTT ratios may order different doses of heparin and produce different levels of anticoagulation in their patients, depending on the sensitivity of APTT reagent used by the laboratory ...
B, Zanke, A M, Shojania
openaire   +2 more sources