Results 11 to 20 of about 42,047 (260)

Routine Lupus Anticoagulant Sensitive aPTT Testing Can Prevent Unnecessary LA Testing

Clinical and Applied Thrombosis/Hemostasis, 2023
Even though routine screening of the general hospital population is discouraged, medical laboratories may use a “lupus sensitive” activated partial thromboplastin time test (aPTT) with phospholipid concentrations that are susceptible to inhibition by ...
Bob Smit PhD, Francisca Hudig PhD, Jan-Hendrik Venhuizen MS, Saskia Haitjema PhD, Maarten Limper MD, PhD, Rolf Urbanus PhD, Albert Huisman PhD   +6 more
doaj   +4 more sources

Investigation on the accelerated pavement test track (APTT) in the development of road network using geopolymer concrete

Cleaner Materials, 2022
Geopolymers produced with fly ash and ground granulated blast furnace slag (GGBFS) are beneficial and environmentally advantageous materials, but their fragility limits their applications.
Ramamohana Reddy Bellum
doaj   +2 more sources

Determinants of the APTT‐ and ETP‐based APC sensitivity tests [PDF]

Journal of Thrombosis and Haemostasis, 2005
A reduced sensitivity for activated protein C (APC) is associated with an increased risk of venous thrombosis even in the absence of the factor (F)V Leiden mutation. This risk has been demonstrated with two APC sensitivity tests, which quantify the effects of APC on the activated partial thromboplastin time (APTT) and the endogenous thrombin potential (
Visser, M.C.H. de, Vlieg, A.V., Tans, G., Rosing, J., Dahm, A.E.A., Sandset, P.M., Rosendaal, F.R., Bertina, R.M.   +7 more
openaire   +3 more sources

Stability of Plasma for Add-On PT and APTT Tests [PDF]

American Journal of Clinical Pathology, 1998
We conducted studies to determine at what time point an add-on prothrombin time (PT) or activated partial thromboplastin time (APTT) test can be honored on specimens that have been received in the laboratory hours earlier without yielding results with clinically significant differences from those if the test had been performed on the original unstored ...
D, Neofotistos, M, Oropeza, C H, Ts'ao
openaire   +2 more sources

Screening coagulation testing using the APTT: Which reagent to choose? [PDF]

American Journal of Hematology, 2010
APTT testing is integral to hemostasis testing. A prolonged result, however, can be difficult to interpret, depending on the APTT reagent's sensitivity to the lupus anticoagulant. This often generates additional laboratory testing for both factor deficiencies and the presence of a lupus anticoagulant, and in so doing, delays patient management. We have
Francine R. Dembitzer, Yvelisse Suarez, Louis M. Aledort, Ellinor I.B. Peerschke   +3 more
openaire   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

APTT Reagents for Different Coagulation Tests: One Size Does Not Fit All [PDF]

American Journal of Clinical Pathology, 2012
To the Editor We read with interest the report by Fritsma et al1 on the recommendations to use more than 1 reagent to screen for lupus anticoagulant (LA) in a hemostasis laboratory. Activated partial thromboplastin time (APTT) reagents supplied by different commercial sources are becoming increasingly specific not only for the presence of LA but also
Shirimati, Shetty, Kanjaksha, Ghosh
openaire   +2 more sources

Nebulized heparin in burn patients with inhalation trauma : safety and feasibility [PDF]

, 2020
Background: Pulmonary hypercoagulopathy is intrinsic to inhalation trauma. Nebulized heparin could theoretically be beneficial in patients with inhalation injury, but current data are conflicting.
Binnekade, Jan M., Cleffken, Berry, Colpaert, Kirsten, Dixon, Barry, Glas, Gerie J., Hollmann, Markus W., Horn, Janneke, Juffermans, Nicole P., Knape, Paul, Levi, Marcel M., Loef, Bert G., Mackie, David P., Malbrain, Manu, Muller, Jan, Preckel, Benedikt, Reidinga, Auke C., Schultz, Marcus J., van der Sluijs, K.F.   +17 more
core   +2 more sources

Correlation of glycated hemoglobin with coagulation profile and hematological parameters in type II diabetes mellitus

Chronic Diseases Journal, 2023
BACKGROUND: Patients with diabetes mellitus (DM) have a high risk of atherothrombotic events, with 80% of patients with DM dying a thrombotic death and 75% of these deaths being due to cardiovascular complications.
Pravinkumar V Ghongade, Bharat Umakant Patil, Vitaladeuni B Shivkumar   +2 more
doaj   +1 more source

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Nature Communications, 2021
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the ...
Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné   +19 more
doaj   +1 more source