Antimicrobial Agents and Chemotherapy, 2020 Mucormycosis is a life-threatening infection with high mortality that occurs predominantly in immunocompromised patients. Manogepix (MGX) is a novel antifungal that targets Gwt1, a protein involved in an early step in the conserved glycosylphosphotidyl ...
Teclegiorgis Gebremariam +2 more
exaly +2 more sources
Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections [PDF]
Journal of Fungi, 2020 Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix is the N-phosphonooxymethylene prodrug of manogepix, an inhibitor
Karen Joy Shaw, Ashraf S. Ibrahim
doaj +2 more sources
Fungal Cytological Profiling of Candida albicans Exposed to Diverse Antifungal Agents Including the Novel Gwt1 inhibitor APX001A [PDF]
Antimicrobial Agents and Chemotherapy, 2017 Background Bacterial cytological profiling accelerates drug discovery efforts by determining the mechanism of action (MOA) of newly developed antibacterial agents.
M. Sharp +3 more
semanticscholar +14 more sources
Antimicrobial Agents and Chemotherapy, 2019 The emerging pathogenic yeast Candida auris is associated with antifungal resistance and high mortality. The novel antifungal agent manogepix (APX001A) inhibits glycosylphosphatidylinositol-anchored protein maturation and has demonstrated activity ...
Nathan P Wiederhold
exaly +2 more sources
Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis [PDF]
Open Forum Infectious Diseases, 2017 Background APX001 is a first-in-class intravenous and orally available broad spectrum antifungal inhibitor of Gwt1, a protein involved in glycosylphosphatidylinositol anchor biosynthesis.
W. Schell +3 more
semanticscholar +2 more sources
Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis [PDF]
Antimicrobial Agents and Chemotherapy, 2020 There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of ...
Teclegiorgis Gebremariam +2 more
exaly +3 more sources
Once-Weekly Liposomal Amphotericin B Use for Maintenance and Consolidation Phase Treatment of Cryptococcal Meningitis in Patients With AIDS. [PDF]
CureusCryptococcal meningitis should be considered in individuals diagnosed with human immunodeficiency virus (HIV) infection and presenting with a cluster of differentiation 4 (CD4)-helper T cell count below 100 cells/ml.
Belinschi V, Iheagwara C, Muhanna A.
europepmc +2 more sources
Evaluation of the In Vitro and In Vivo Antifungal Activity of APX001A/APX001 Against Candida auris [PDF]
Open Forum Infectious Diseases, 2017 Background Candida auris, an emerging multidrug-resistant yeast, causes deadly invasive infections with high mortality. C. auris strains often show high MICs to fluconazole and amphotericin B, and some are resistant to all 3 major antifungal classes ...
Emily L. Larkin +4 more
semanticscholar +2 more sources
Drug Discovery and Repurposing for <i>Coccidioides</i>: A Systematic Review. [PDF]
J Fungi (Basel)<i>Coccidioides immitis</i> and <i>C. posadasii</i> are the causative agents of coccidioidomycosis (CM) or Valley Fever, endemic to the alkaline deserts of North and South America. Clinical treatment of CM is predominantly limited
Saeger S +5 more
europepmc +3 more sources