Results 1 to 10 of about 456 (124)

Structural insights into the inhibition mechanism of fungal GWT1 by manogepix [PDF]

Nature Communications
Glycosylphosphatidylinositol (GPI) acyltransferase is crucial for the synthesis of GPI-anchored proteins. Targeting the fungal glycosylphosphatidylinositol acyltransferase GWT1 by manogepix is a promising antifungal strategy.
Dong Deng, Wang Xiang, Chuangye Yan
exaly   +7 more sources

Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

Journal of Fungi (Basel, Switzerland), 2022
Invasive fungal infections have mortality rates of 30–90%, depending on patient co-morbidities and the causative pathogen. The frequent emergence of drug resistance reduces the efficacy of currently approved treatment options, highlighting an urgent need
Sean D Liston, Luke Whitesell, Leah E Cowen   +2 more
exaly   +5 more sources

Antimicrobial activity of manogepix, a first-in-class antifungal, and comparator agents tested against contemporary invasive fungal isolates from an international surveillance programme (2018–2019)

Journal of Global Antimicrobial Resistance, 2021
: Objectives: : Manogepix, the active moiety of the prodrug fosmanogepix, is a novel antifungal with activity against major fungal pathogens including Candida (except Candida krusei), Aspergillus and difficult-to-treat/rare moulds.
Michael D Huband, Mariana Castanheira
exaly   +5 more sources

In Vitro Antifungal Activity of Manogepix and Other Antifungal Agents against South African Candida auris Isolates from Bloodstream Infections

Microbiology Spectrum, 2022
We determined the susceptibility of South African Candida auris bloodstream surveillance isolates to manogepix, a novel antifungal, and several registered antifungal agents. C. auris isolates were submitted to a reference laboratory between 2016 and 2017.
Tsidiso G. Maphanga, Ruth S. Mpembe, Serisha D. Naicker, Nelesh P. Govender   +3 more
doaj   +3 more sources

Antifungal Susceptibility of Clinical <i>Meyerozyma guillermondii</i> Isolates Obtained Between 1994 and 2014: Original Research and Comparison with Published Data. [PDF]

Pathogens
(1) Background: Meyerozyma guilliermondii is a yeast species widely distributed in the natural environment and one of the rare emerging pathogens capable of causing difficult to treat, severe infections.
Górzyńska A, Konarska D, Korzeniowska-Kowal A, Wzorek A, Pencakowski B, Nawrot U.   +5 more
europepmc   +2 more sources

Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis [PDF]

mBio, 2022
Cryptococcal Meningitis (CM) is uniformly fatal if not treated, and treatment options are limited. We previously reported on the activity of APX2096, the prodrug of the novel Gwt1 inhibitor APX2039, in a mouse model of CM.
Charles D. Giamberardino, Wiley A. Schell, Jennifer L. Tenor, Dena L. Toffaletti, Julia R. Palmucci, Choiselle Marius, Jane-Valeriane K. Boua, Quinlyn Soltow, Robert Mansbach, M. Arthur Moseley, J. Will Thompson, Laura G. Dubois, William Hope, John R. Perfect, Karen Joy Shaw   +14 more
doaj   +4 more sources

Novel Antifungals and Aspergillus Section Terrei with Potpourri Susceptibility Profiles to Conventional Antifungals. [PDF]

J Fungi (Basel), 2023
The epidemiology of invasive fungal infections (IFIs) is currently changing, driven by aggressive immunosuppressive therapy, leading to an expanded spectrum of patients at risk of IFIs.
Vahedi-Shahandashti R, Houbraken J, Birch M, Lass-Flörl C.   +3 more
europepmc   +2 more sources

Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections

Journal of Fungi (Basel, Switzerland), 2020
Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix is the N-phosphonooxymethylene prodrug of manogepix, an inhibitor
Karen Joy Shaw, Ashraf S Ibrahim
exaly   +3 more sources

Echinocandin tolerance and persistence <i>in vitro</i> are regulated by calcineurin signaling in <i>Candida glabrata</i>. [PDF]

mBio
Upon exposure to echinocandins, growing yeast cells begin to accumulate cell wall damage and eventually die, resulting in therapeutic effects. While resistance to echinocandins is well studied, tolerance and persistence mechanisms that may also ...
Harrington AA, Nickels TJ, Cunningham KW.   +2 more
europepmc   +2 more sources

Antifungal Susceptibility of <i>Saccharomyces cerevisiae</i> Isolated from Clinical Specimens. [PDF]

Pathogens
(1) Background: Despite being considered a non-pathogenic yeast, recently, a growing occurrence of Saccharomyces cerevisiae infections has been noted. There is little knowledge about the drug susceptibility of this species.
Górzyńska A, Kondracka K, Korzeniowska-Kowal A, Nawrot U.   +3 more
europepmc   +2 more sources