Multi-omic characterization of the maize GPI synthesis mutant gwt1 with defects in kernel development [PDF]
BMC Plant Biology, 2023 Background Glycosylphosphatidylinositol (GPI) and GPI-anchored proteins (GAPs) are important for cell wall formation and reproductive development in Arabidopsis.
Zhang Xuehai +2 more
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The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level [PDF]
Smart moleculesPhotoswitchable bioactive molecules have attracted more attention and are widely used as photochromic ligands (PCLs) in both agrochemicals and pharmaceuticals.
Xusheng Shao, Wen Fu
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Structural insights into the inhibition mechanism of fungal GWT1 by manogepix [PDF]
Nature CommunicationsGlycosylphosphatidylinositol (GPI) acyltransferase is crucial for the synthesis of GPI-anchored proteins. Targeting the fungal glycosylphosphatidylinositol acyltransferase GWT1 by manogepix is a promising antifungal strategy.
Wang Xiang, Hanmin Liu, Yaozong Li
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Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens [PDF]
Journal of Fungi, 2022 Invasive fungal infections have mortality rates of 30–90%, depending on patient co-morbidities and the causative pathogen. The frequent emergence of drug resistance reduces the efficacy of currently approved treatment options, highlighting an urgent need
Sean D. Liston +4 more
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Baicalin promotes β-1,3-glucan exposure in Candida albicans and enhances macrophage response [PDF]
Frontiers in Cellular and Infection MicrobiologyAmong the diverse fungal opportunistic pathogens, Candida albicans garners significant attention due to its wide range of infections and high frequency of occurrence.
Yiyuan Pan +14 more
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Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections [PDF]
Journal of Fungi (Basel, Switzerland), 2020 Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix is the N-phosphonooxymethylene prodrug of manogepix, an inhibitor
Karen Joy Shaw
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Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against Aspergillus fumigatus [PDF]
The Cell SurfaceFosmanogepix is a new antifungal agent currently undergoing phase 3 clinical trials. Its active moiety, manogepix, inhibits Gwt1 which is an enzyme essential for the assembly and attachment of glycosylphosphatidylinositol anchors to cell wall proteins ...
Sean Brazil +4 more
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New Perspectives on Antimicrobial Agents: Fosmanogepix [PDF]
Antimicrobial Agents and ChemotherapyInvasive fungal infections (IFIs) are associated with high mortality rates and pose important therapeutic challenges because of the limited number of antifungal drug classes, their toxicity, and the emergence of resistance.
Frederic Lamoth
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Manogepix demonstrates potent in vitro activity against Aspergillus, Coccidioides, Scopulariopsis/Microascus, Rasamsonia, and Purpureocillium species, including strains with in vitro resistance to other antifungals [PDF]
Antimicrobial Agents and ChemotherapyManogepix, the active moiety of the prodrug fosmanogepix, is a novel investigational agent in clinical trials that inhibits Gwt1, depleting glycosylphosphatidylinositol (GPI)-anchored mannoproteins critical for fungal cell wall integrity.
Nathan P. Wiederhold +3 more
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Novel Inositol Acyltransferase (Gwt1) Inhibitor for Fungal Keratitis Treatment: Evaluation of In Vitro and In Vivo Efficacy and Safety [PDF]
Invest Ophthalmol Vis SciNirmal J, Sanhita Roy, Bhupesh Bagga
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