Results 21 to 30 of about 552 (107)

Antifungal chemotherapies and immunotherapies for the future

Parasite Immunology, Volume 45, Issue 2, February 2023., 2023
Abstract Human fungal pathogens cause a broad plethora of infections, spanning cutaneous dermatophytoses to invasive infections in immunocompromised hosts. As eukaryotic pathogens are capable of morphotype switching, they present unique challenges both for drug development and the immunological response.
Darius Armstrong‐James
wiley   +1 more source

Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding

Journal of Computational Chemistry, Volume 43, Issue 32, Page 2121-2130, December 15, 2022., 2022
The co‐crystal structure of an imidazopyridine ligand (1) complex with Candida albicans Bdf1 BD2, a novel anti‐fungal drug target, reveals that one (W1) among six structural water molecules has been displaced. Molecular dynamic simulations provided insight into the mechanistic role of the displacement process.
Yingsheng Zhou, Justin M. Overhulse, Nathan J. Dupper, Yanchun Guo, Boris A. Kashemirov, Kaiyao Wei, Jérôme Govin, Carlo Petosa, Charles E. McKenna   +8 more
wiley   +1 more source

Similarities and Differences among Species Closely Related to Candida albicans: C. tropicalis, C. dubliniensis, and C. auris

Cellular Microbiology, Volume 2022, Issue 1, 2022., 2022
Although Candida species are widespread commensals of the microflora of healthy individuals, they are also among the most important human fungal pathogens that under certain conditions can cause diseases (candidiases) of varying severity ranging from mild superficial infections of the mucous membranes to life‐threatening systemic infections.
Dorota Satala, Magdalena Juszczak, Ewelina Wronowska, Magdalena Surowiec, Kamila Kulig, Andrzej Kozik, Maria Rapala-Kozik, Justyna Karkowska-Kuleta, Sanket Kaushik   +8 more
wiley   +1 more source

Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future

Clinical Pharmacology &Therapeutics, Volume 109, Issue 4, Page 867-891, April 2021., 2021
Model‐informed drug development (MIDD) has a long and rich history in infectious diseases. This review describes foundational principles of translational anti‐infective pharmacology, including choice of appropriate measures of exposure and pharmacodynamic (PD) measures, patient subpopulations, and drug‐drug interactions.
Craig R. Rayner, Patrick F. Smith, David Andes, Kayla Andrews, Hartmut Derendorf, Lena E. Friberg, Debra Hanna, Alex Lepak, Edward Mills, Thomas M. Polasek, Jason A. Roberts, Virna Schuck, Mark J. Shelton, David Wesche, Karen Rowland‐Yeo   +14 more
wiley   +1 more source

Clinical safety and efficacy of novel antifungal, fosmanogepix, for the treatment of candidaemia: results from a Phase 2 trial [PDF]

, 2023
BACKGROUND: Fosmanogepix is a first-in-class antifungal targeting the fungal enzyme Gwt1, with broad-spectrum activity against yeasts and moulds, including multidrug-resistant fungi, formulated for intravenous (IV) and oral administration.
Barbat, Sara H, Hodges, Michael, Ilana Oren, Mccarty, Todd, Oborska, Iwona, Hodges, Michael R, Rahav, Galia, Thompson, George, Bien, Paul A, Todd Mccarty, Barbat, Sara S.H., Bulpa, Pierre, Jose A Vazquez, Roca, Ricard Ferrer, Ronen Ben-Ami, Pappas, Peter P.G., Pamela Wedel, Galia Rahav, Vazquez, José J.A., Michael R Hodges, Vazquez, Jose, Pappas, Peter, Paul A Bien, Tawadrous, Margaret, Schlamm, Haran, Thompson, George R, Barbat, Sara, Ricard Ferrer, Pappas, Peter G, Bien, Paul, Pierre Bulpa, Haran Schlamm, Aoun, Michel, Mickael Aoun, Sara H Barbat, George R Thompson, Iwona Oborska, Bien, Paul P.A., Aoun, Mickael, Peter G Pappas, Margaret Tawadrous, Ben-Ami, Ronen, Wedel, Pamela, Thompson, George G.R., Oren, Ilana, Ferrer, Ricard, Vazquez, Jose A   +46 more
core   +3 more sources

Cytotoxic and Antifungal Amides Derived from Ferulic Acid: Molecular Docking and Mechanism of Action

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Amides derived from ferulic acid have a wide spectrum of pharmacological activities, including antitumor and antifungal activity. In the present study, a series of ten amides were obtained by coupling reactions using the reagents (benzotriazol‐1‐yloxy) tripyrrolidinophosphonium hexafluorophosphate (PyBOP) and N,N ′ -dicyclohexylcarbodiimide (DCC).
Mayara Castro de Morais, Yunierkis Perez-Castillo, Valdenizia Rodrigues Silva, Luciano de Souza Santos, Milena Botelho Pereira Soares, Daniel Pereira Bezerra, Ricardo Dias de Castro, Damião Pergentino de Sousa, Nahide Gulsah Deniz   +8 more
wiley   +1 more source

A proteomic analysis of lipid raft and GPI anchored proteins in Caenorhabditis elegans [PDF]

, 2010
Glycosylphosphatidylinositol (GPI) anchored proteins are a unique group of membrane proteins found on the surface and certain intracellular compartments of eukaryotic cells.
Rao, Wei
core   +6 more sources

APX001 and Other Gwt1 inhibitor Prodrugs are Effective in Experimental Coccidioides immitis Pneumonia [PDF]

, 2018
non
Fierer, Joshua, Kapoor, Mili, Shaw, Karen Joy, Covel, Jonathan, Viriyakosol, Suganya, Okamoto, Sharon, Soltow, Quinlyn A, Trzoss, Michael   +7 more
core   +1 more source

Additional file 2 of Multi-omic characterization of the maize GPI synthesis mutant gwt1 with defects in kernel development

, 2023
Supplementary Material
Dong Ding (112949), Jihua Tang (155382), Sarah Jane Hearne (15269425), Shirong Bo (15269422), Runmiao Tian (15269419), Hui Zhang (7197), Xuehai Zhang (2405686), Jianjun Jiang (395680), Zhiyuan Fu (155361)   +8 more
core   +1 more source

Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus. [PDF]

, 2020
Mucormycosis is a life-threatening infection with high mortality that occurs predominantly in immunocompromised patients. Manogepix (MGX) is a novel antifungal that targets Gwt1, a protein involved in an early step in the conserved glycosylphosphotidyl ...
Patterson, Thomas F, Gebremariam, Teclegiorgis, Ibrahim, Ashraf S, Shaw, Karen Joy, Alkhazraji, Sondus, Alqarihi, Abdullah, Wiederhold, Nathan P, Filler, Scott G   +7 more
core   +1 more source