Results 31 to 40 of about 552 (107)
, 2014 Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals.
Sandra Koseoglu +59 more
core +1 more source
International Journal of Microbiology, Volume 2014, Issue 1, 2014., 2014 Protein glycosylation pathways are present in all kingdoms of life and are metabolic pathways found in all the life kingdoms. Despite sharing commonalities in their synthesis, glycans attached to glycoproteins have species‐specific structures generated by the presence of different sets of enzymes and acceptor substrates in each organism. In this review,
Iván Martínez-Duncker +3 more
wiley +1 more source
, 2012 In fungi, the anchoring of proteins to the plasma membrane via their covalent attachment to glycosylphosphatidylinositol (GPI) is essential and thus provides a valuable point of attack for the development of antifungal therapeutics.
Mazitschek, Ralph +5 more
core +1 more source
Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis [PDF]
, 2020 There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of ...
Mamouei, Zeinab +8 more
core +1 more source
Mycoses, Volume 69, Issue 9, September 2026.ABSTRACT Background Central nervous system (CNS) aspergillosis is a life‐threatening infection with mortality rates exceeding 50%, especially in immunocompromised patients. Significant challenges persist due to limited antifungal drug penetration into the CNS, emerging resistance, and diagnostic delays, despite advancements in therapy and diagnostics ...
Moustafa A. Mansour +5 more
wiley +1 more source
, 2016 In fungi, the anchoring of proteins to the plasma membrane via their covalent attachment to glycosylphosphatidylinositol (GPI) is essential and thus provides a valuable point of attack for the development of antifungal therapeutics.
Luke Whitesell (477573) +5 more
core +1 more source
Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass
Plant Direct, Volume 10, Issue 1, January 2026.ABSTRACT Rice straw is a key source of lignocellulosic biomass. GWAS can be used to identify genetic loci controlling stem morphological traits that influence biomass. This study aimed to investigate the genotypic diversity of rice straw internodes through GWAS, using 34,232 single‐nucleotide polymorphic sites with a minor allelic frequency (MAF ...
Mahta Mohamadiaza +4 more
wiley +1 more source
Pest Management Science, Volume 81, Issue 10, Page 6567-6578, October 2025.High biological activity of pyridazine carboxamides against a wide range of Ascomycetes led to identification of a new biochemical target for agrochemical fungicides – serine palmitoyl transferase. Abstract BACKGROUND Plant pathogens pose a significant threat to global agriculture and, thus to world food supplies, requiring the development of ...
Lionel Nicolas +13 more
wiley +1 more source