Results 41 to 50 of about 552 (107)
, 2012 Continued research toward the development of new antifungals that act via inhibition of glycosylphosphatidylinositol (GPI) biosynthesis led to the design of E1210. In this study, we assessed the selectivity of the inhibitory activity of E1210 against
Kappei Tsukahara +5 more
core +1 more source
Antifungal Resistance in Non‐fumigatus Aspergillus Species
Mycoses, Volume 68, Issue 4, April 2025.ABSTRACT This review provides an in‐depth exploration of antifungal resistance in non‐fumigatus Aspergillus species, mainly focusing on acquired resistance. The available data have been compiled and sometimes re‐analysed. It highlights the increasing prevalence of resistance in non‐fumigatus species belonging to Flavi, Terrei, Nigri, and Nidulantes ...
Elie Djenontin +3 more
wiley +1 more source
The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies
Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley +1 more source
Антибиотики и ХимиотерапияBackground. Invasive mycoses pose a growing health threat, especially for patients with weakened immune systems, whose number is increasing due to advances in oncology, transplantation, and intensive care.
A. V. Avtonomova +3 more
doaj +1 more source
New and emerging options for management of invasive fungal diseases in paediatric patients
Mycoses, Volume 67, Issue 1, January 2024.Abstract Invasive fungal diseases (IFDs) play an important role in the supportive care of paediatric patients with acute leukaemia and those undergoing allogeneic haematopoietic cell transplantation, and they are associated with significantly decreased overall survival rates in affected individuals.
Andreas H. Groll +3 more
wiley +1 more source
APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis [PDF]
, 2019 Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed ...
Gebremariam, Teclegiorgis +7 more
core +1 more source
Planning and synthesis of analogues of the manogepix as antifungal agents
, 2022 Anualmente, as infecções fúngicas invasivas (IFIs) são responsáveis pela morte de aproximadamente 1,5 – 2 milhões de pacientes. O tratamento atual com antifúngicos é limitada e o aumento da resistência aos fármacos demanda pela busca de novos agentes ...
Deberaldini, Maria Gabriela
core
Characterization of APX001A Resistance and the Underlying Mechanisms in Cryptococcus Neoformans [PDF]
, 2018 Title Characterization of APX001A resistance and underlying mechanisms in Cryptococcus neoformans Company AMPLYX PHARMACEUTICALS Author Chithirachelvi Vasudevan Defense date 18th April, 2018 Program Professional Science Masters Biotechnology School ...
Chithirachelvi Vasudevan
core
In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris
, 2018 Candida auris is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality. C.
Christopher L. Hager +5 more
core +1 more source
Fosmanogepix (FMGX) is the prodrug of manogepix (MGX), which targets Gwt1, an inositol acyltransferase encoded by GWT1 and required for glycosylphosphatidylinositol anchor biosynthesis.
Tatsuro Hirayama +12 more
core +1 more source