Results 51 to 60 of about 552 (107)

Perturbing glycosylphosphatidylinositol (GPI)-anchor biosynthesis alters cell wall architecture and modulates fungal morphology

Filamentous fungi are widely used for industrial protein production, but dense mycelial pellets can restrict nutrient and oxygen transfer and reduce fermentation efficiency.
Isha Gautam, Surya Pavan Yenamandra, Tuo Wang, Prakash Arumugam, Hui Ting Chu   +4 more
core   +1 more source

Issue Information

Smart Molecules, Volume 4, Issue 3, September 2026.
No abstract is available for this article.
wiley   +1 more source

In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

, 2018
Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans , is uniformly fatal if not treated. Treatment options are limited, especially in resource-poor geographical regions, and mortality rates ...
Molly Moloney, Jennifer L. Tenor, Quinlyn A. Soltow, Gisele Duboc, Peter Webb, John R. Perfect, Dena L. Toffaletti, Mili Kapoor, Karen Joy Shaw, Michael Trzoss, Jonathan Covel, C. Giamberardino, Wiley A. Schell   +12 more
core   +1 more source

In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model

, 2018
APX001 is the prodrug of APX001A, which is a first-in-class small molecule with a unique mechanism of action that inhibits the fungal enzyme Gwt1 in the glycosylphosphatidylinositol (GPI) biosynthesis pathway.
Paul G. Ambrose, Karen Marchillo, David R. Andes, Miao Zhao, Brian VanScoy, Justin C. Bader, Alexander J. Lepak, Jamie Vanhecker   +7 more
core   +1 more source

Gwt1 Inhibitor APX001

, 2020

core   +1 more source

Identification of GPI-Anchored Wall Transfer Protein 1 Modulators for Fungal Infections Through Generative AI and Physics-Based Approaches. [PDF]

Int J Mol Sci
Alsarra IA, Chikhale R, Al-Mohizea AM, Islam MA.   +3 more
europepmc   +1 more source

Discovery of a new chemical scaffold for the treatment of superbug Candida auris infections. [PDF]

Emerg Microbes Infect, 2023
Tu J, Zhu T, Wang Q, Yang W, Huang Y, Xu D, Liu N, Sheng C.   +7 more
europepmc   +1 more source

Use of Expanded Access Fosmanogepix in Two Pediatric Patients With Rhino-Orbital-Cerebral Mucormycosis. [PDF]

Pharmacotherapy
Oldham MM, Buckendorf G, Elmitwalli I, Sparling DP, Tyungu DL.   +4 more
europepmc   +1 more source

The Upcoming Antifungal Drugs in Clinical Development for the Treatment of Invasive Candidiasis. [PDF]

Infect Drug Resist
Zubovskaia A, Vazquez JA.
europepmc   +1 more source

New trends in antifungal treatment: What is coming up? [PDF]

Rev Esp Quimioter, 2023
Guinea J.
europepmc   +1 more source