The importance of antimicrobial resistance in medical mycology. [PDF]
, 2022 Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O'Neill report, have predicted that deaths due to drug-resistant bacterial infections may eclipse the total number ...
Berman, J +11 more
core +2 more sources
1282. Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In vitro Activity Against Members of the Fusarium oxysporum and Fusarium solani Species Complexes [PDF]
Open Forum Infectious Diseases, 2020 Abstract Background Invasive fusariosis is associated with marked morbidity and mortality in immunocompromised hosts, and treatment options are limited. Common etiologic agents include members of the F. oxysporum and F. solani species complexes (FOSC and FSSC, respectively).
Badali, Hamid +9 more
openaire +1 more source
Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing [PDF]
, 2022 This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new ...
core +1 more source
Antimicrobial Agents and Chemotherapy, 2020 Manogepix (APX001A) is the active moiety of the novel drug candidate fosmanogepix (APX001). We previously reported the broad-spectrum activity of manogepix but also observed a correlation between increased manogepix and fluconazole MICs. Here, we extended this study and included isolates with acquired fluconazole resistance. Isolates (
Maiken Cavling Arendrup +1 more
openaire +4 more sources
Drug Discovery and Repurposing for <i>Coccidioides</i>: A Systematic Review. [PDF]
J Fungi (Basel)<i>Coccidioides immitis</i> and <i>C. posadasii</i> are the causative agents of coccidioidomycosis (CM) or Valley Fever, endemic to the alkaline deserts of North and South America. Clinical treatment of CM is predominantly limited
Saeger S +5 more
europepmc +3 more sources
Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex [PDF]
, 2021 Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis inducing pathogens, because they are endowed with proper virulence factors ...
Auw-Hädrich, Claudia +9 more
core +1 more source
Epidemiologia, biologia, resistência a antifúngicos e virulência do fungo emergente Candida auris: Epidemiology, biology, antifungal resistance and virulence of the emerging fungus Candida auris [PDF]
, 2022 Introdução: A Candida auris é uma nova espécie de patógeno fúngico altamente resistente e emergente que causa infecções invasivas graves. O objetivo desse estudo é realizar um levantamento sobre o gênero Candida, destacando características gerais ...
de Barros, Neuza Biguinati +2 more
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Invasive Candida infection: epidemiology, clinical and therapeutic aspects of an evolving disease and the role of rezafungin [PDF]
, 2023 Introduction: Invasive Candida Infections (ICIs) have undergone a series of significant epidemiological, pathophysiological, and clinical changes during the last decades, with a shift toward non-albicans species, an increase in the rate of exogenous ...
De Rosa, Francesco Giuseppe +1 more
core +5 more sources
Antifungal Resistance in Non‐fumigatus Aspergillus Species
Mycoses, Volume 68, Issue 4, April 2025.ABSTRACT This review provides an in‐depth exploration of antifungal resistance in non‐fumigatus Aspergillus species, mainly focusing on acquired resistance. The available data have been compiled and sometimes re‐analysed. It highlights the increasing prevalence of resistance in non‐fumigatus species belonging to Flavi, Terrei, Nigri, and Nidulantes ...
Elie Djenontin +3 more
wiley +1 more source
Advances in the Treatment of Invasive Fungal Disease [PDF]
, 2023 With over 300 million severe cases and 1.5 million deaths annually, invasive fungal diseases (IFDs) are a major medical burden and source of global morbidity and mortality.
An, Zhiqiang +2 more
core +1 more source