Architecture of the dynamic fungal cell wall
, 2023 The fungal cell wall is essential for growth and survival, and is a key target for antifungal drugs and the immune system. The cell wall must be robust but flexible, protective and shielding yet porous to nutrients and membrane vesicles and receptive to ...
Gow, NAR, Lenardon, MD
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The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies
Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley +1 more source
Multidrug resistance mechanisms and therapeutic strategies in Candida auris [PDF]
In recent years, Candida auris has emerged as a formidable global health threat due to its multidrug resistance, high transmissibility in healthcare settings, and diagnostic challenges. Unlike most Candida species, C. auris can colonize the skin, persist
Alkaabi, Sara
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Predictors for prolonged hospital stay solely to complete intravenous antifungal treatment in patients with candidemia: Results from the ECMM candida III multinational European observational cohort study [PDF]
, 2023 Background To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates of azole resistance among non-albicans Candida spp. continue to increase.
Alastruey-Izquierdo, Ana +53 more
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Virulence traits and novel drug delivery strategies for mucormycosis post-COVID-19: a comprehensive review [PDF]
, 2023 The outbreak of a fatal black fungus infection after the resurgence of the cadaverous COVID-19 has exhorted scientists worldwide to develop a nutshell by repurposing or designing new formulations to address the crisis.
A. Sophia +22 more
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Estudio de la resistencia a los antifúngicos en hongos patógenos humanos [PDF]
, 2019 Las mejoras en el diagnóstico, el tratamiento y el cuidado de pacientes inmunodeprimidos han incrementado su tasa de supervivencia, pero también han dado lugar al aumento progresivo de otras enfermedades, como las infecciones fúngicas invasoras.
Rivero Menéndez, Olga
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Action Mechanisms of Medicinal Plant Components as Antimycosis: A Literature Review [PDF]
Mycosis poses a significant threat to global health, particularly in immune-compromised individuals, and the rise of antifungal resistance has further complicated their treatment.
Abusalim, Ghadah S. +3 more
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Septic arthritis as breakthrough invasive fusariosis after cord blood transplantation [PDF]
A 63-year-old male received a third allogeneic hematopoietic stem cell transplantation with voriconazole prophylaxis for relapsed acute myeloid leukemia.
Ando, Koji +16 more
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Planejamento e síntese de análogos do manogepix como agentes antifúngicos
, 2022 Pós-graduação em Química ...
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Candida Auris Features and its Treatment: Global Emergency [PDF]
Fungal pathogen Candida auris was identified in 2009, in Japan. Currently, it is identified in 5 continents, in more than 40 countries. Therefore, it is nowadays defined as critical priority pathogen.
Durán, Nelson +2 more
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