APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis
Antimicrobial Agents and Chemotherapy, 2018 Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed ...
Teclegiorgis Gebremariam +7 more
semanticscholar +1 more source
The global challenge of Candida auris in the intensive care unit [PDF]
, 2019 Since the first isolation of Candida auris in 2009, scientific community has witnessed an exponential emergence of infection episodes and outbreaks in different world regions. It is hard to predict future C. auris diffusion.
Bassetti, Matteo +4 more
core +4 more sources
The combination of manogepix and itraconazole is synergistic and inhibits the growth of Madurella mycetomatis in vitro but not in vivo [PDF]
, 2023 Mycetoma is a neglected tropical disease commonly caused by the fungus Madurella mycetomatis. Standard treatment consists of extensive treatment with itraconazole in combination with surgical excision of the infected tissue, but has a low success rate ...
Eadie, Kimberly +6 more
core
Hope on the horizon: Novel fungal treatments in development [PDF]
, 2020 The treatment of invasive fungal infections remains challenging due to limitations in currently available antifungal therapies including toxicity, interactions, restricted routes of administration, and drug resistance.
Coler-Reilly, Ariella +3 more
core +1 more source
Aspergillus fumigatus and aspergillosis: From basics to clinics [PDF]
, 2021 The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by causing numerous invasive infections and a notable mortality in humans, especially in immunocompromised patients.
Aljohani, R +20 more
core +1 more source
The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies
Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley +1 more source
Candida auris: a quick review on identification, current treatments, and challenges [PDF]
, 2021 Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of ...
Brás, Susana Maria Pereira +4 more
core +1 more source
Chitosan ameliorates Candida auris virulence in a Galleria mellonella infection model [PDF]
, 2020 Candida auris has emerged as a multi-drug resistant nosocomial pathogen over the last decade. Outbreaks of the organism in healthcare facilities has resulted in life-threatening invasive candidiasis in over 40 countries worldwide. Resistance by C.
Arias, Laís Salomão +9 more
core +2 more sources
Future challenges and chances in the diagnosis and management of invasive mould infections in cancer patients. [PDF]
, 2020 Diagnosis, treatment, and management of invasive mould infections (IMI) are challenged by several risk factors, including local epidemiological characteristics, the emergence of fungal resistance and the innate resistance of emerging pathogens, the use ...
Koehler, P. +6 more
core +4 more sources
Target product profile and discovery and development path for novel cryptococcal disease treatments [PDF]
Cryptococcus neoformans and Cryptococcus gattii are World Health Organization critical and medium priority pathogens, respectively. These mainly impact people with human immunodeficiency virus residing in low- and middle-income countries, but other ...
De Rycker, Manu +11 more
core +4 more sources