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Detecting aquaporin function and regulation
Frontiers in Chemistry, 2016 Water is the major component of cells and tissues throughout all forms of life. Fluxes of water and solutes through cell membranes and epithelia are essential for osmoregulation and energy homeostasis. Aquaporins are membrane channels expressed in almost
Ana eMadeira +3 more
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Frontiers in Pharmacology, 2022 In sickle cell disease (SCD), the pathological shift of red blood cells (RBCs) into distorted morphologies under hypoxic conditions follows activation of a cationic leak current (Psickle) and cell dehydration.
Pak Hin Chow +10 more
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Ravulizumab in Aquaporin‐4–Positive Neuromyelitis Optica Spectrum Disorder
Annals of Neurology, 2023 CHAMPION‐NMOSD (NCT04201262) is a phase 3, open‐label, externally controlled interventional study evaluating the efficacy and safety of the terminal complement inhibitor ravulizumab in adult patients with anti–aquaporin‐4 antibody–positive (AQP4 ...
S. Pittock +14 more
semanticscholar +1 more source
MYC is a metastasis gene for non-small-cell lung cancer. [PDF]
, 2009 Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Castro, Inês +8 more
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Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Brain : a journal of neurology, 2021 Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at the glia limitans, where it mediates water exchange across the ...
M. Salman +8 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies.
V. Damato +22 more
semanticscholar +1 more source
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
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Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression
Scientific Reports, 2021 Exposure to arsenic, a ubiquitous metalloid on Earth, results in human cancers. Skin cancer is the most common arsenical cancers. Both autophagy and aquaporin pathway are known to promote carcinogenesis. However, the mechanisms by which arsenic regulates
Sebastian Yu +5 more
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Exploring aquaporin functions during changes in leaf water potential
Frontiers in Plant Science, 2023 Maintenance of optimal leaf tissue humidity is important for plant productivity and food security. Leaf humidity is influenced by soil and atmospheric water availability, by transpiration and by the coordination of water flux across cell membranes ...
Caitlin S. Byrt +5 more
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Recombinant production of human Aquaporin-1 to an exceptional high membrane density in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2013 In the present paper we explored the capacity of yeast Saccharomyces cerevisiae as host for heterologous expression of human Aquaporin-1. Aquaporin-1 cDNA was expressed from a galactose inducible promoter situated on a plasmid with an adjustable copy ...
Julie Bomholt +3 more
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