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Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease [PDF]
Cells, 2019 Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions.
Simone Mader, Lior Brimberg
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Regulation of Aquaporin Z osmotic permeability in ABA tri-block copolymer
AIMS Biophysics, 2015 Aquaporins are transmembrane water channel proteins present in biological plasma membranes that aid in biological water filtration processes by transporting water molecules through at high speeds, while selectively blocking out other kinds of solutes ...
Wenyuan Xie +4 more
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Crystal Structure of an Ammonia-Permeable Aquaporin
PLoS Biology, 2016 Aquaporins of the TIP subfamily (Tonoplast Intrinsic Proteins) have been suggested to facilitate permeation of water and ammonia across the vacuolar membrane of plants, allowing the vacuole to efficiently sequester ammonium ions and counteract cytosolic ...
Andreas Kirscht +8 more
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Detecting aquaporin function and regulation
Frontiers in Chemistry, 2016 Water is the major component of cells and tissues throughout all forms of life. Fluxes of water and solutes through cell membranes and epithelia are essential for osmoregulation and energy homeostasis. Aquaporins are membrane channels expressed in almost
Ana eMadeira +3 more
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Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). [PDF]
, 2013 Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased
Armstrong, Stephen P +4 more
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Frontiers in Pharmacology, 2022 In sickle cell disease (SCD), the pathological shift of red blood cells (RBCs) into distorted morphologies under hypoxic conditions follows activation of a cationic leak current (Psickle) and cell dehydration.
Pak Hin Chow +10 more
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Ravulizumab in Aquaporin‐4–Positive Neuromyelitis Optica Spectrum Disorder
Annals of Neurology, 2023 CHAMPION‐NMOSD (NCT04201262) is a phase 3, open‐label, externally controlled interventional study evaluating the efficacy and safety of the terminal complement inhibitor ravulizumab in adult patients with anti–aquaporin‐4 antibody–positive (AQP4 ...
S. Pittock +14 more
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Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Brain : a journal of neurology, 2021 Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at the glia limitans, where it mediates water exchange across the ...
M. Salman +8 more
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Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies.
V. Damato +22 more
semanticscholar +1 more source
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
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