Results 201 to 210 of about 38,213 (256)

Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants

open access: yesClinical Genetics, Volume 110, Issue 2, Page 203-209, August 2026.
We identified a novel pathogenic AVP variant in two Danish families with autosomal dominant inheritance of symptoms of AVP deficiency. In addition, we compiled a catalogue of additionally 109 AVP variants that cause AVP deficiency and demonstrated the advantage of combining expert‐assisted curation, literature search, and online repositories to ensure ...
Jennifa Joseph   +5 more
wiley   +1 more source

Rapid dehydration drives a nondiffusional drop in C3 photosynthesis that aligns with phosphate limitation

open access: yesNew Phytologist, Volume 251, Issue 3, Page 1127-1142, August 2026.
Schematic representation of the causal sequence through which rapid water loss imposes diffusive and nondiffusive restrictions on carbon assimilation. Summary Drought is an abnormally prolonged water deficit posing major challenges to plants. Stomatal closure has long been considered the primary factor limiting photosynthesis during the early stages of
Chandra Bellasio   +4 more
wiley   +1 more source

Physiology and Transcriptomics Reveal Divergent Strategies of Mycorrhiza‐Mediated Drought Adaptation in Poplar

open access: yesPlant, Cell &Environment, Volume 49, Issue 8, Page 5078-5094, August 2026.
ABSTRACT Mycorrhizal symbiosis shapes plant growth and stress resilience. Here, we compared physiological and molecular responses of poplars (P. x canescens) colonised by Paxillus involutus (Pi) or Cenococcum geophilum (Cg) under control conditions, drought stress and recovery.
Huili Shi, Zhuchou Lu, Andrea Polle
wiley   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

open access: yesAdvanced Science, Volume 13, Issue 38, 9 July 2026.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok   +4 more
wiley   +1 more source

Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery

open access: yesAlzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood. METHODS Using aged mice, we examined the impact of abdominal surgery on cognition, glymphatic activity, and astrocyte function.
Yuto Hasegawa   +13 more
wiley   +1 more source

Diagnostic Challenges and Clinical Management of Area Postrema Syndrome: A Case Report on Persistent Nausea and Vomiting

open access: yesClinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Area postrema syndrome (APS) is a rare neurological syndrome that presents a significant diagnostic challenge due to its nonspecific clinical manifestations, most commonly persistent nausea and vomiting, which frequently lead to initial misdiagnosis as a gastrointestinal disorder.
Andreea‐Gabriela Manole   +4 more
wiley   +1 more source

A Case of Longitudinal Extensive Transversal Myelitis in Patient With Neuromyelitis Optica Spectrum Disorder and Systemic Lupus Erythematosus

open access: yesClinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune, demyelinating disorder of the central nervous system. Clinical manifestations include optic neuritis, longitudinally extensive transverse myelitis (LETM) involving three or more vertebral segments, and, in most cases, seropositivity for anti‐aquaporin‐4 antibodies (AQP4‐IgG).
Nikolina Pravdic   +7 more
wiley   +1 more source

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72‐Year Journey of Pediatric‐Onset to Secondary Progressive Multiple Sclerosis

open access: yesClinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system characterized by cumulative neurological disability over time. Median survival from symptom onset in large cohort studies is approximately four decades, although substantially prolonged disease courses are uncommon.
Masoud Etemadifar   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy