Results 211 to 220 of about 38,256 (256)
MedComm, Volume 7, Issue 8, August 2026.Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min +4 more
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SIRT Family: Biological Functions and Therapeutic Targets
MedComm, Volume 7, Issue 8, August 2026.SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang +9 more
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Glucose Transporter 1 in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai +3 more
wiley +1 more source
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Expression of aquaporin 2 in human endometrium
Fertility and Sterility, 2006To study the expression of aquaporin-2 (AQP2) in human endometrium.Prospective clinical study.Hospital-based unit for gynecology and obstetrics and research laboratories.Healthy women with proven fertility who were divided into four groups according to LH peak.Endometrial biopsies were obtained from 34 women on cycle days LH+4 to LH+14.Localization of ...
Kristina Gemzell-Danielsson +2 more
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Kidney International, 2023
Arginine-vasopressin induces water reabsorption in collecting duct principal cells through the water channels aquaporin (AQP) 2, 3, and 4. Only the presence of these AQPs allows for short-term adjustments of plasma osmolality by arginine-vasopressin. How principal cells maintain the expression of the AQPs is unclear.
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Arginine-vasopressin induces water reabsorption in collecting duct principal cells through the water channels aquaporin (AQP) 2, 3, and 4. Only the presence of these AQPs allows for short-term adjustments of plasma osmolality by arginine-vasopressin. How principal cells maintain the expression of the AQPs is unclear.
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Role of microRNAs in aquaporin 2 regulation
Current Opinion in Nephrology & Hypertension, 2022Purpose of review The current review aims to present the most recent achievements on the role of microRNAs (miRNAs) on the kidney function to stimulate research in the field and to expand new emerging concepts. Recent findings The focus is on the role of miRNAs in intercellular ...
Petrillo, Federica +1 more
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The vasopressin–aquaporin-2 pathway syndromes
2021Vasopressin is the key hormone involved in water conservation and regulation of water balance, essential for life. In the renal collecting duct, vasopressin binds to the V2 receptor, increasing water permeability through activation of aquaporin-2 redistribution to the luminal membrane.
Valenti G., Tamma G.
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Regulation of Aquaporin-2 Trafficking
2009Principal cells lining renal collecting ducts control the fine-tuning of body water homeostasis by regulating water reabsorption through the water channels aquaporin-2 (AQP2), aquaporin-3 (AQP3), and aquaporin-4 (AQP4). While the localization of AQP2 is subject to regulation by arginine-vasopressin (AVP), AQP3 and AQP4 are constitutively expressed in ...
NEDVETSKY P. I +5 more
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2004
Regulation of the water permeability of the apical plasma membrane in collecting duct principal cells is essential for the regulation of renal water excretion, and thus, the regulation of body water balance. The water permeability is partly regulated by trafficking of aquaporin (AQP2) containing vesicles between an intracellular reservoir and the ...
Frische, S.; id_orcid 0000-0002-0270-3602 +3 more
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Regulation of the water permeability of the apical plasma membrane in collecting duct principal cells is essential for the regulation of renal water excretion, and thus, the regulation of body water balance. The water permeability is partly regulated by trafficking of aquaporin (AQP2) containing vesicles between an intracellular reservoir and the ...
Frische, S.; id_orcid 0000-0002-0270-3602 +3 more
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Regulation of aquaporin-2 by RNA interference
2020MicroRNAs (miRNAs) are short non-coding RNAs that interact with 3'-untranslated regions of mRNAs. miRNAs modulate gene expression by regulating mRNA translation and provide novel insights into the complex regulation of protein expression and function. In this chapter, we describe the general features of RNA interference, identification of miRNAs, and ...
Hyun Jun, Jung +3 more
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