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A Genetic Reporter for Visualizing Nitroreductase Activity Using Magnetic Resonance Imaging

Chemistry–Methods, Volume 6, Issue 5, May 2026.
We introduce a reporter gene technology to noninvasively visualize bacterial nitroreductase activity. Our method utilizes a magnetic resonance imaging (MRI) reporter based on aquaporin, which is fused to a destabilizing domain, resulting in their degradation (off‐state).
Jinyang Wan, Asish N. Chacko, Emrys Xu, Kiran Kuriakose, Arnab Mukherjee   +4 more
wiley   +1 more source

Virtual Screening of Traditional Chinese Medicine Natural Product Inhibitors Targeting AQP1 for Bladder Cancer

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Bladder cancer (BCa) is the most common and representative type of adult urinary tract urothelial cancer, characterized by high incidence and mortality rates. It has become a major disease threatening public health, highlighting the urgent need for the development of comprehensive treatment strategies, including traditional Chinese ...
Di Liu, Qing‐Yu Zhang
wiley   +1 more source

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Aquaporin-2 is not alone

Kidney International, 2023
Arginine-vasopressin induces water reabsorption in collecting duct principal cells through the water channels aquaporin (AQP) 2, 3, and 4. Only the presence of these AQPs allows for short-term adjustments of plasma osmolality by arginine-vasopressin. How principal cells maintain the expression of the AQPs is unclear.
openaire   +2 more sources

Role of microRNAs in aquaporin 2 regulation

Current Opinion in Nephrology & Hypertension, 2022
Purpose of review The current review aims to present the most recent achievements on the role of microRNAs (miRNAs) on the kidney function to stimulate research in the field and to expand new emerging concepts. Recent findings The focus is on the role of miRNAs in intercellular ...
Petrillo, Federica, Trepiccione, Francesco   +1 more
openaire   +4 more sources

The vasopressin–aquaporin-2 pathway syndromes

2021
Vasopressin is the key hormone involved in water conservation and regulation of water balance, essential for life. In the renal collecting duct, vasopressin binds to the V2 receptor, increasing water permeability through activation of aquaporin-2 redistribution to the luminal membrane.
Valenti G., Tamma G.
openaire   +3 more sources

Regulation of Aquaporin-2 Trafficking

2009
Principal cells lining renal collecting ducts control the fine-tuning of body water homeostasis by regulating water reabsorption through the water channels aquaporin-2 (AQP2), aquaporin-3 (AQP3), and aquaporin-4 (AQP4). While the localization of AQP2 is subject to regulation by arginine-vasopressin (AVP), AQP3 and AQP4 are constitutively expressed in ...
NEDVETSKY P. I, BEULSHAUSEN S, ROSENTHAL W, KLUSSMANN E., TAMMA, GRAZIA, VALENTI, Giovanna   +5 more
openaire   +3 more sources

Expression of aquaporin 2 in human endometrium

Fertility and Sterility, 2006
To study the expression of aquaporin-2 (AQP2) in human endometrium.Prospective clinical study.Hospital-based unit for gynecology and obstetrics and research laboratories.Healthy women with proven fertility who were divided into four groups according to LH peak.Endometrial biopsies were obtained from 34 women on cycle days LH+4 to LH+14.Localization of ...
Anna, Hildenbrand, Luther, Lalitkumar, Soren, Nielsen, Kristina, Gemzell-Danielsson, Anneli, Stavreus-Evers   +4 more
openaire   +2 more sources

Regulation of aquaporin-2 by RNA interference

2020
MicroRNAs (miRNAs) are short non-coding RNAs that interact with 3'-untranslated regions of mRNAs. miRNAs modulate gene expression by regulating mRNA translation and provide novel insights into the complex regulation of protein expression and function. In this chapter, we describe the general features of RNA interference, identification of miRNAs, and ...
Hyun Jun, Jung, Eui-Jung, Park, Hyo-Jung, Choi, Tae-Hwan, Kwon   +3 more
openaire   +2 more sources

Repressive regulation of the aquaporin-2 gene

American Journal of Physiology-Renal Physiology, 1996
Expression of aquaporin-2 (AQP2) is exclusively limited to kidney collecting duct cells, and this strictly limited expression could be mediated by transcription of the gene. We first examined AQP2 mRNA expression in many cultured epithelial cells derived from kidney.
M, Furuno, S, Uchida, F, Marumo, S, Sasaki   +3 more
openaire   +2 more sources

Aquaporin-2 in the human endolymphatic sac

Acta Oto-Laryngologica, 2004
To detect and localize aquaporin-2 (AQP-2), a water channel regulated by the antidiuretic hormone, in human endolymphatic sac.Human endolymphatic sacs were sampled during removal of vestibular schwannomas via a translabyrinthine approach. Samples were immediately fixed in 10% formalin (24 h) and embedded in paraffin; in situ hybridization and ...
Vincent, Couloigner, Dominique, Berrebi, Marie, Teixeira, Régine, Paris, Agnès, Florentin, Alexis, Bozorg Grayeli, Françoise, Cluzeaud, Olivier, Sterkers, Michel, Peuchmaur, Evelyne, Ferrary   +9 more
openaire   +2 more sources