Results 261 to 270 of about 41,663 (295)
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2004
Regulation of the water permeability of the apical plasma membrane in collecting duct principal cells is essential for the regulation of renal water excretion, and thus, the regulation of body water balance. The water permeability is partly regulated by trafficking of aquaporin (AQP2) containing vesicles between an intracellular reservoir and the ...
Frische, S.; id_orcid 0000-0002-0270-3602 +3 more
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Regulation of the water permeability of the apical plasma membrane in collecting duct principal cells is essential for the regulation of renal water excretion, and thus, the regulation of body water balance. The water permeability is partly regulated by trafficking of aquaporin (AQP2) containing vesicles between an intracellular reservoir and the ...
Frische, S.; id_orcid 0000-0002-0270-3602 +3 more
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Urinary aquaporin-2 in children with acute pyelonephritis
Pediatric Nephrology, 2005Children with acute pyelonephritis develop polyuria and have reduced maximum urinary concentration capacity. We studied whether these abnormalities are associated with altered urinary excretion of the water channel aquaporin-2 (AQP2) in the renal collecting duct.
Rodionova, Elena A. +7 more
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Aquaporin-2 protein dynamics within the cell
Current Opinion in Nephrology & Hypertension, 2007Aquaporin-2 is an aquaporin water channel protein present at the apical membrane of kidney collecting duct cells and plays a key role in urine concentrating ability. Like other membrane proteins, aquaporin-2 undergoes dynamic processes within the cells: synthesized, targeted to the subapical region, exocytosed to the apical membrane, endocytosed ...
Sei, Sasaki, Yumi, Noda
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Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus
Seminars in Nephrology, 2008Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone vasopressin (AVP). When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from ...
Loonen, A.J.M. +3 more
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Estrogen regulates aquaporin-2 expression in the kidney
2020Estrogens are primarily identified as sex hormones that, for a long time, have been known as important regulators of female reproductive physiology. However, our understanding of the role of estrogens has changed over the past years. It is now well accepted that estrogens are also involved in other physiological and pathological processes in both ...
Tingskov, Stine Julie; id_orcid 0000-0002-9427-404X +2 more
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New insights into regulated aquaporin-2 function
Current Opinion in Nephrology and Hypertension, 2013Aquaporin-2 (AQP2) water channels in principal cells of the kidney collecting duct are essential for urine concentration. Due to application of modern technologies, progress in our understanding of AQP2 has accelerated in recent years. In this article, we highlight some of the new insights into AQP2 function that have developed recently, with ...
Fenton, Robert A; id_orcid 0000-0003-1623-199X +2 more
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The ins and outs of aquaporin-2 trafficking
American Journal of Physiology-Renal Physiology, 2003This review outlines recent advances related to the molecular mechanisms and pathways of aquaporin-2 (AQP2) water channel trafficking. AQP2 is a fascinating protein, whose sorting signals can be interpreted by different cell types to achieve apical or basolateral membrane insertion, in both regulated and constitutive trafficking pathways.
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Physiology and pathophysiology of the aquaporin-2 water channel
Current Opinion in Nephrology and Hypertension, 1998Aquaporins are integral membrane proteins, which function as specialized water channels to facilitate the passage of water through the cell membrane. In mammals six different aquaporins have been identified up to now, four of which (aquaporin-1 to aquaporin-4) are expressed in the kidney.
Deen, P.M.T., Knoers, N.V.A.M.
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Urinary aquaporin‐2 levels in healthy volunteers
Nephrology, 2003SUMMARY: Renal water handling is regulated by the release of arginine vasopressin (AVP) and the subsequent insertion of aquaporin 2 (AQP2) in the apical membrane of collecting duct cells. This in turn increases the membrane permeability to water and the passive reabsorption of water down the concentration gradient present in the medulla.
Ali, Al-Dameh +3 more
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Pathophysiology of Aquaporin-2 in Water Balance Disorders
The American Journal of the Medical Sciences, 1998The recent identification of aquaporin water channel proteins has provided detailed information about the molecular basis for transepithelial water transport. At least five aquaporins have been identified in the kidney; they have provided detailed molecular insight into the fundamental physiology of water balance.
J, Frøkiaer +3 more
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