Results 261 to 270 of about 24,621,355 (297)

Aquaporin-2 trafficking

2004
Regulation of the water permeability of the apical plasma membrane in collecting duct principal cells is essential for the regulation of renal water excretion, and thus, the regulation of body water balance. The water permeability is partly regulated by trafficking of aquaporin (AQP2) containing vesicles between an intracellular reservoir and the ...
Sebastian Frische, Tae-Hwan Kwon, Jørgen Frøkiær, Søren Nielsen   +3 more
openaire   +3 more sources

Regulation of aquaporin-2 by RNA interference

2020
MicroRNAs (miRNAs) are short non-coding RNAs that interact with 3'-untranslated regions of mRNAs. miRNAs modulate gene expression by regulating mRNA translation and provide novel insights into the complex regulation of protein expression and function. In this chapter, we describe the general features of RNA interference, identification of miRNAs, and ...
Hyun Jun, Jung, Eui-Jung, Park, Hyo-Jung, Choi, Tae-Hwan, Kwon   +3 more
openaire   +2 more sources

Repressive regulation of the aquaporin-2 gene

American Journal of Physiology-Renal Physiology, 1996
Expression of aquaporin-2 (AQP2) is exclusively limited to kidney collecting duct cells, and this strictly limited expression could be mediated by transcription of the gene. We first examined AQP2 mRNA expression in many cultured epithelial cells derived from kidney.
M, Furuno, S, Uchida, F, Marumo, S, Sasaki   +3 more
openaire   +2 more sources

Aquaporin-2 in the human endolymphatic sac

Acta Oto-Laryngologica, 2004
To detect and localize aquaporin-2 (AQP-2), a water channel regulated by the antidiuretic hormone, in human endolymphatic sac.Human endolymphatic sacs were sampled during removal of vestibular schwannomas via a translabyrinthine approach. Samples were immediately fixed in 10% formalin (24 h) and embedded in paraffin; in situ hybridization and ...
Vincent, Couloigner, Dominique, Berrebi, Marie, Teixeira, Régine, Paris, Agnès, Florentin, Alexis, Bozorg Grayeli, Françoise, Cluzeaud, Olivier, Sterkers, Michel, Peuchmaur, Evelyne, Ferrary   +9 more
openaire   +2 more sources

Urinary aquaporin-2 in children with acute pyelonephritis

Pediatric Nephrology, 2005
Children with acute pyelonephritis develop polyuria and have reduced maximum urinary concentration capacity. We studied whether these abnormalities are associated with altered urinary excretion of the water channel aquaporin-2 (AQP2) in the renal collecting duct.
Rodionova, Elena A., Kuznetsova, Alla A., Shakhmatova, Elena I., Prutskova, Natalia, Nielsen, Søren, Holtbäck, Ulla, Natochin, Yuri, Zelenina, Marina   +7 more
openaire   +3 more sources

Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus

Seminars in Nephrology, 2008
Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone vasopressin (AVP). When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from ...
Loonen, A.J.M., Knoers, N.V.A.M., Os, C.H. van, Deen, P.M.T.   +3 more
openaire   +3 more sources

Aquaporin-2 protein dynamics within the cell

Current Opinion in Nephrology & Hypertension, 2007
Aquaporin-2 is an aquaporin water channel protein present at the apical membrane of kidney collecting duct cells and plays a key role in urine concentrating ability. Like other membrane proteins, aquaporin-2 undergoes dynamic processes within the cells: synthesized, targeted to the subapical region, exocytosed to the apical membrane, endocytosed ...
Sei, Sasaki, Yumi, Noda
openaire   +2 more sources

Estrogen regulates aquaporin-2 expression in the kidney

2020
Estrogens are primarily identified as sex hormones that, for a long time, have been known as important regulators of female reproductive physiology. However, our understanding of the role of estrogens has changed over the past years. It is now well accepted that estrogens are also involved in other physiological and pathological processes in both ...
Tingskov, Stine Julie; id_orcid 0000-0002-9427-404X, Mutsaers, Henricus A M; id_orcid 0000-0002-9553-8860, Nørregaard, Rikke; id_orcid 0000-0002-0580-373X   +2 more
openaire   +3 more sources

New insights into regulated aquaporin-2 function

Current Opinion in Nephrology and Hypertension, 2013
Aquaporin-2 (AQP2) water channels in principal cells of the kidney collecting duct are essential for urine concentration. Due to application of modern technologies, progress in our understanding of AQP2 has accelerated in recent years. In this article, we highlight some of the new insights into AQP2 function that have developed recently, with ...
Fenton, Robert A; id_orcid 0000-0003-1623-199X, Pedersen, Cecilie Noehr, Moeller, Hanne B   +2 more
openaire   +3 more sources

Urinary aquaporin‐2 levels in healthy volunteers

Nephrology, 2003
SUMMARY:  Renal water handling is regulated by the release of arginine vasopressin (AVP) and the subsequent insertion of aquaporin 2 (AQP2) in the apical membrane of collecting duct cells. This in turn increases the membrane permeability to water and the passive reabsorption of water down the concentration gradient present in the medulla.
Ali, Al-Dameh, Jennifer J, Bedford, John P, Leader, Robert J, Walker   +3 more
openaire   +2 more sources