Results 61 to 70 of about 77,865 (353)

Genome-wide identification, structure characterization, and expression pattern profiling of aquaporin gene family in cucumber

BMC Plant Biology, 2019
Aquaporin (AQP) proteins comprise a group of membrane intrinsic proteins (MIPs) that are responsible for transporting water and other small molecules, which is crucial for plant survival under stress conditions including salt stress.
Yongxing Zhu, Lei Y. Yang, Ning Liu, Jie Yang, Xiaokang Zhou, Yu-Chen Xia, Yang He, Yi-qin He, H. Gong, D. Ma, Junlong Yin   +10 more
semanticscholar   +1 more source

Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Patients carrying the carbonic anhydrase12 E143K mutation showed the dry mouth phenotype. The mechanism underlying the modulation of aquaporin 5 and function in the salivary glands by carbonic anhydrase12 remains unknown. In this study, we identified the
Soyoung Hwang, Jung Yun Kang, Min Jae Kim, Dong Min Shin, Jeong Hee Hong   +4 more
doaj   +1 more source

Aquaporin-4

Rinsho Shinkeigaku, 2008
In human body, there are thirteen water channels but their expression patterns are tissue specific. Aquaporin-4 (AQP4) is a predominantly expressed water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder, and mesial temporal lobe epilepsy.
Tani, Kazutoshi, Hiroaki, Yoko, Fujiyoshi, Yoshinori   +2 more
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl

, 2012
It is generally considered that the bladder is impervious and stores urine in unmodified form on account of the barrier imposed by the highly-specialised uro-epithelial lining.
Lisa A Kirkwood, Kirkwood Lisa A., Rubenwolf, Peter C., Jennifer Southgate, Georgopoulos, Nikolaos T., Georgopoulos Nikolaos T., Rubenwolf Peter C., Kirkwood, Lisa A., Baker Simon C., Peter C Rubenwolf, Southgate, Jennifer, Southgate Jennifer, Baker, Simon C., Simon C Baker, Nikolaos T Georgopoulos   +14 more
core   +1 more source

Inhibitors of Mammalian Aquaporin Water Channels

International Journal of Molecular Sciences, 2019
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural biology of the AQP family is well-established and
Mohammed Abir-Awan, P. Kitchen, M. Salman, M. Conner, A. Conner, R. Bill   +5 more
semanticscholar   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

2D-crystallization and 3D-structures of membrane channels and transporters [PDF]

, 2004
Membrane proteins are responsible for a broad spectrum of biological functions such as signal transduction, structural functions, energy conversion or transport of matter across the membranes.
Braun, Thomas
core   +1 more source

Aquaporins in endothelia [PDF]

Kidney International, 2006
Aquaporin-1 (AQP1) water channels are expressed widely in microvascular endothelia outside of the central nervous system, including renal vasa recta and tumor microvessels, as well as in non-vascular endothelia in pleura, peritoneum, cornea, and lymphatics.
openaire   +2 more sources