Results 61 to 70 of about 52,178 (309)

The Eucalyptus Tonoplast Intrinsic Protein (TIP) gene subfamily: genomic organization, structural features and expression profiles

Frontiers in Plant Science, 2016
Plant aquaporins are water channels implicated in various physiological processes, including growth, development and adaptation to stress. In this study, the Tonoplast Intrinsic Protein (TIP) gene subfamily of Eucalyptus, an economically important woody ...
Marcela Iara Rodrigues, Agnes Alessandra Sekijima Takeda, Agnes Alessandra Sekijima Takeda, Juliana Pereira Bravo, Ivan G. Maia   +4 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

The AQP2 mutation V71M causesnephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog

FEBS Open Bio, 2015
Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causesnephrogenic diabetes insipidus in ...
Noreen Klein, Nadine Kümmerer, Dominika Hobernik, Dirk Schneider   +3 more
doaj   +1 more source

The physiological response of Populus tremula x alba leaves to the down-regulation of PIP1 aquaporin gene expression under no water stress.

Frontiers in Plant Science, 2013
In order to study the role of PIP1 aquaporins in leaf water and CO2 transport, several lines of PIP1-deficient transgenic Populus tremula x alba were generated using a reverse genetic approach. These transgenic lines displayed no visible developmental or
Francesca eSecchi, Maciej Andrzej Zwieniecki   +1 more
doaj   +1 more source

Characterization of an Aquaporin Gene ZpPIP2 from Zygophyllum potaninii [PDF]

Mongolian Journal of Biological Sciences, 2016
Zygophyllum potaninii Maxim. is a medicinal plant, distributed in arid regions of southern Mongolia. Full length of a cDNA clone, which was identifi ed as a stress induced gene by suppression subtractive hybridization was obtained by 5’RACEPCR, and ...
Bayarmaa Gun-Aajav, Munkhbileg Enkhbat, Oyuntsetseg Batlai   +2 more
doaj   +1 more source

Finding Aquaporins in Annelids: An Evolutionary Analysis and a Case Study

Cells, 2021
Aquaporins (AQPs) are a family of membrane channels facilitating diffusion of water and small solutes into and out of cells. Despite their biological relevance in osmoregulation and ubiquitous distribution throughout metazoans, the presence of AQPs in ...
Serena Mucciolo, Andrea Desiderato, Marika Salonna, Tomasz Mamos, Viviane Prodocimo, Maikon Di Domenico, Francesco Mastrototaro, Paulo Lana, Carmela Gissi, Giuseppe Calamita   +9 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica. [PDF]

, 2011
In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown to be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated T cells in PBMCs during NMO relapses.
Goto, Hirofumi, M. Komori, K.-P. Wandinger, Kondo, Takayuki, K. Nomura, H. Matsuo, Shiraishi, Hirokazu, Wandinger, Klaus-Peter, Matsuo, Hidenori, T. Fukudome, H. Shiraishi, Komori, Mika, Fukudome, Takayasu, S. Nakane, Nakane, Shunya, Nomura, Kyouichi, Matsuya, Nemu, H. Goto, N. Matsuya, T. Kondo   +19 more
core   +1 more source

Updated diagnostic criteria for neuromyelitis optica spectrum disorder: Similar outcomes of previously separate cohorts

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background The specificity of the aquaporin-4 antibody to predict recurrent inflammatory central nervous system disease has led to the design of the 2015 neuromyelitis optica spectrum disorder criteria which capture all aquaporin-4 antibody seropositive ...
M McCreary, MA Mealy, DM Wingerchuk, M Levy, A DeSena, BM Greenberg   +5 more
doaj   +1 more source