Results 161 to 170 of about 37,019 (222)

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz   +8 more
wiley   +1 more source

Disrupting BMP/TGF‐β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells

open access: yesComprehensive Physiology, Volume 15, Issue 6, December 2025.
Evaluation of targeted gene silencing and exogenous BMP9 administration in HPMECs. AQP1 silencing decreased TGFB1, TGFBR1, and BMPR2 expression, while BMP9 administration returned TGFB1 to basal levels. TGFB1 silencing upregulated BMP9, while downregulating BMP10 and BMPR2 expression. BMP9 administration downregulated AQP1 expression.
Chrysi Keskinidou   +8 more
wiley   +1 more source

Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage

open access: yesGlia, Volume 73, Issue 12, Page 2386-2406, December 2025.
Main Points NBCe1 is upregulated in reactive astrocytes following ischemic stroke. Deletion of astrocytic Nboe1 reduces stroke volume, preserves AQP4 polarization, reduces BBB permeability, and improves neurological function after ischemic stroke. ABSTRACT The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in ...
Okan Capuk   +16 more
wiley   +1 more source

Dysregulation of astrocytic Aquaporin-1 in the brains of oldest-old rhesus macaques: the NIA caloric restriction study. [PDF]

open access: yesGeroscience
Stayer-Wilburn O   +13 more
europepmc   +1 more source

Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis

open access: yesGlia, Volume 73, Issue 12, Page 2407-2426, December 2025.
Main Points DEOs are similar to satellite glial cells. DECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. ECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs)
Katja Senf   +3 more
wiley   +1 more source

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