Molecular Characterization of an Aquaporin−2 Mutation Causing Nephrogenic Diabetes Insipidus [PDF]
Frontiers in Endocrinology, 2021 The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis. AQP2 mutation leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, polydipsia, and hypernatremia.
Qian Li +10 more
doaj +4 more sources
Updates and Perspectives on Aquaporin-2 and Water Balance Disorders. [PDF]
Int J Mol Sci, 2021 Ensuring the proper amount of water inside the body is essential for survival. One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2).
Noda Y, Sasaki S.
europepmc +2 more sources
miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury. [PDF]
Ren Fail, 2021 Objective This study was designed to uncover the mechanism of miR-34b-5p-mediated aquaporin-2 (AQP2) in sepsis-induced injury using human renal tubular epithelial cells (HK-2). Methods Serum levels of miR-34b-5p, TNF-α, IL-1β, IL-6, serum creatinine (SCr)
Zheng C, Wu D, Shi S, Wang L.
europepmc +2 more sources
Comparative quantitation of aquaporin-2 and arginine vasopressin receptor-2 localizations among chronic kidney disease and healthy kidney in dogs [PDF]
Veterinary World, 2021 Background and Aim: Aquaporin-2 (AQP2) and arginine vasopressin receptor-2 (AVPR2) are proteins that control water homeostasis in principal cells. Chronic kidney disease (CKD) is defined as the impairment and irreversible loss of kidney function and/or ...
Pitchaya Matchimakul +3 more
doaj +2 more sources
Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone [PDF]
Frontiers in Cell and Developmental BiologyIntroductionSeveral aquaporins (AQPs) are involved in the influx of water to form follicular fluid, and AQP2 may play a crucial role in follicular growth.
Zetong Zheng +15 more
doaj +2 more sources
α-Actinin 4 Links Vasopressin Short-Term and Long-Term Regulation of Aquaporin-2 in Kidney Collecting Duct Cells [PDF]
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
doaj +2 more sources
A multiscale model of the regulation of aquaporin 2 recycling [PDF]
npj Systems Biology and Applications, 2022 The response of cells to their environment is driven by a variety of proteins and messenger molecules. In eukaryotes, their distribution and location in the cell are regulated by the vesicular transport system.
Christoph Leberecht +2 more
doaj +2 more sources
Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct [PDF]
, 1997 We tested whether severe congestive heart failure (CHF), a condition associated with excess free-water retention, is accompanied by altered regulation of the vasopressin-regulated water channel, aquaporin-2 (AQP2), in the renal collecting duct.
Andersen, D. +8 more
core +4 more sources
A Case of Congenital Nephrogenic Diabetes Insipidus Caused by Thr108Met Variant of Aquaporin 2 [PDF]
Frontiers in Pediatrics, 2020 Congenital nephrogenic diabetes insipidus (CNDI) is a rare renal disorder caused by mutations in arginine vasopressin receptor 2 (AVPR2) or aquaporin 2 (AQP2). The clinical signs of CNDI include polyuria, compensatory polydipsia, dehydration, electrolyte
Lina Ma +7 more
doaj +2 more sources
Vasopressin-induced serine 269 phosphorylation reduces Sipa1l1 (signal-induced proliferation-associated 1 like 1)-mediated aquaporin-2 endocytosis [PDF]
Journal of Biological Chemistry, 2017 The abundance of integral membrane proteins in the plasma membrane is determined by a dynamic balance between exocytosis and endocytosis, which can often be regulated by physiological stimuli.
Po-Jen Wang +6 more
openalex +2 more sources