Results 281 to 290 of about 64,606 (299)

New insights into regulated aquaporin-2 function

Current Opinion in Nephrology and Hypertension, 2013
Aquaporin-2 (AQP2) water channels in principal cells of the kidney collecting duct are essential for urine concentration. Due to application of modern technologies, progress in our understanding of AQP2 has accelerated in recent years. In this article, we highlight some of the new insights into AQP2 function that have developed recently, with ...
Fenton, Robert A, Pedersen, Cecilie Noehr, Moeller, Hanne B   +2 more
openaire   +3 more sources

Aquaporin-2 in the human endolymphatic sac

Acta Oto-Laryngologica, 2004
To detect and localize aquaporin-2 (AQP-2), a water channel regulated by the antidiuretic hormone, in human endolymphatic sac.Human endolymphatic sacs were sampled during removal of vestibular schwannomas via a translabyrinthine approach. Samples were immediately fixed in 10% formalin (24 h) and embedded in paraffin; in situ hybridization and ...
Vincent, Couloigner, Dominique, Berrebi, Marie, Teixeira, Régine, Paris, Agnès, Florentin, Alexis, Bozorg Grayeli, Françoise, Cluzeaud, Olivier, Sterkers, Michel, Peuchmaur, Evelyne, Ferrary   +9 more
openaire   +2 more sources

Urinary aquaporin‐2 levels in healthy volunteers

Nephrology, 2003
SUMMARY:  Renal water handling is regulated by the release of arginine vasopressin (AVP) and the subsequent insertion of aquaporin 2 (AQP2) in the apical membrane of collecting duct cells. This in turn increases the membrane permeability to water and the passive reabsorption of water down the concentration gradient present in the medulla.
Ali, Al-Dameh, Jennifer J, Bedford, John P, Leader, Robert J, Walker   +3 more
openaire   +2 more sources

Aquaporin-2 vasopressin water channel

Clinical and Experimental Nephrology, 1999
Aquaporin-2 (AQP2) is present in the apical membrane of the kidney collecting duct and is regulated by vasopressin-dependent trafficking between the apical membrane and endosomal reservoirs. The molecular structure of AQP2 seems to be somehow different from that of AQP1 in that the third and fourth hydrophilic loops are significant in the formation of ...
openaire   +1 more source

Urinary aquaporin-2 in children with acute pyelonephritis

Pediatric Nephrology, 2005
Children with acute pyelonephritis develop polyuria and have reduced maximum urinary concentration capacity. We studied whether these abnormalities are associated with altered urinary excretion of the water channel aquaporin-2 (AQP2) in the renal collecting duct.
Rodionova, Elena A., Kuznetsova, Alla A., Shakhmatova, Elena I., Prutskova, Natalia, Nielsen, Søren, Holtbäck, Ulla, Natochin, Yuri, Zelenina, Marina   +7 more
openaire   +3 more sources

Calcium signaling in vasopressin-induced aquaporin-2 trafficking

Pflügers Archiv - European Journal of Physiology, 2007
It has been the general consensus that cAMP-mediated PKA-dependent phosphorylation of aquaporin-2 is the primary mechanism of vasopressin to regulate osmotic water permeability in kidney collecting duct. By using laser scanning confocal microscopy to monitor [Ca2+]i and apical exocytosis in individual cells of inner medullary collecting duct, we have ...
Lavanya, Balasubramanian, James S K, Sham, Kay-Pong, Yip   +2 more
openaire   +2 more sources

Cell biology of vasopressin-regulated aquaporin-2 trafficking

Pflügers Archiv - European Journal of Physiology, 2012
Whole-body water balance is predominantly controlled by the kidneys, which have the ability to concentrate or dilute the urine in the face of altered fluid and solute intake. Regulated water excretion is controlled by various hormones and signaling molecules, with the antidiuretic hormone arginine vasopressin (AVP) playing an essential role ...
Moeller, Hanne B, Fenton, Robert A.
openaire   +3 more sources

Lithium reduces aquaporin-2 transcription independent of prostaglandins

American Journal of Physiology-Cell Physiology, 2012
Vasopressin (AVP)-stimulated translocation and transcription of aquaporin-2 (AQP2) water channels in renal principal cells is essential for urine concentration. Twenty percent of patients treated with lithium develop nephrogenic diabetes insipidus (NDI), a disorder in which the kidney is unable to concentrate urine. In vivo and in mouse collecting duct
Kortenoeven, Marleen, Schweer, Horst, Cox, Rik, Wetzels, Jack, Deen, Peter   +4 more
openaire   +4 more sources

Urinary aquaporin-2 excretion during early human development

Pediatric Nephrology, 2006
This study was undertaken to assess one of the determinants of kidney concentrating capacity, aquaporin-2 (AQP2), in order to understand the physiopathology of water balance in newborn babies. Urinary AQP2 excretion has been shown to be proportional to AQP2 level in the apical plasma membrane of the kidney collecting ducts and has been suggested as a ...
Marina, Zelenina, Yanhong, Li, Isabelle, Glorieux, Catherine, Arnaud, Christelle, Cristini, Stéphane, Decramer, Anita, Aperia, Charlotte, Casper   +7 more
openaire   +2 more sources

Aquaporin-2 regulates cell volume recovery via tropomyosin

The International Journal of Biochemistry & Cell Biology, 2009
Cell volume regulation is particularly important for kidney collecting duct cells. These cells are the site of water reabsorption regulated by vasopressin and aquaporin-2 (AQP2) trafficking to the apical membrane, and subject to changes in osmolality. Here, we examined the role of AQP2 in regulatory volume decrease (RVD), which is a cellular defensive ...
Yu-Hua, Li, Kayoko, Eto, Saburo, Horikawa, Shinichi, Uchida, Sei, Sasaki, Xue-Jun, Li, Yumi, Noda   +6 more
openaire   +2 more sources