Results 61 to 70 of about 999,360 (267)
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
, 1994 KF-Al2O3 is discovered to promote epoxidation of electron deficient alkenes. Functional groups that are labile to aqueous basic conditions survive. The steric demand for the reaction is higher than that for alkaline H2O2.
Veejendra K. Yadav +3 more
core +1 more source
Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome.
PLoS ONE, 2017 Sjögren's syndrome (SS) is a chronic, autoimmune exocrinopathy that leads to severe dryness of the mouth and eyes. Exocrine function is highly regulated by neuronal mechanisms but little is known about the link between chronic inflammation, innervation ...
Feeling Y Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency
Ophthalmology, 1999 To evaluate corneal surface regularity and the effect of artificial tears on the regularity of the corneal surface in dry eye.A prospective, clinic-based, case-control study.A total of 64 eyes of 33 normal subjects and 42 eyes of 22 patients with aqueous tear deficiency were evaluated.Indices of the TMS-1 corneal topography instrument (Tomey Technology,
Z, Liu, S C, Pflugfelder
openaire +2 more sources
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans. [PDF]
PLoS ONE, 2010 BACKGROUND: Glaucoma is a leading cause of blindness worldwide. Nonetheless, the mechanism of its pathogenesis has not been well-elucidated, particularly at the molecular level, because of insufficient availability of experimental genetic animal models ...
Keiko Fujikawa +9 more
doaj +1 more source
Impression cytology implicates cell autophagy in aqueous deficiency dry eye
Clinical Ophthalmology, 2017 Impression cytology in combination with a cell autophagy marker was used to demonstrate the utility of a novel frozen section technique, to assess the health of the ocular surface, as well as to correlate autophagic cell death with the commonly used clinical tests for dry eye.Female patients over the age of 18 years who attended an outpatient ...
Lin,Tony +5 more
openaire +5 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Facile One-Pot Synthesis of 2,3,5-Substituted 1,2,4-Oxadiazolines from Nitriles in Aqueous Solution
, 2016 Alkyl/aryl amidoximes, prepared from the corresponding nitriles and N-alkylhydroxylamines, have readily undergone consecutive Michael additions to electron-deficient alkynes and provided highly substituted 1,2,4-oxadiazolines in good yields in ...
Margaret E. Sorenson (2687947) +1 more
core +1 more source