Results 91 to 100 of about 1,849,870 (344)

Effect of drug–polymer interactions on the aqueous solubility of milled solid dispersions

, 2013
The role of molecular interactions in ball milled solid dispersions in determining the aqueous solubility of the poorly water-soluble drug, griseofulvin (GF) has been examined.
Sonal Shah, Al-Obaidi, Hisham, Al-Saden, Noor, Henna Moghul, Moghul, Henna, Lawrence, M. Jayne, Shah, Sonal, Hisham Al-Obaidi, Noor Al-Saden, M. Jayne Lawrence, Fiza Bari, Bari, Fiza   +11 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Studies on the absorption of beta-carotene and the distribution of total carotenoid in human serum lipoproteins after oral administration*

Journal of Lipid Research, 1962
The carotenoid increment in human serum was measured after the oral administration of aqueous dispersions and lipid dispersions of β-carotene with different test meal regimens. β-carotene was readily absorbed in both forms.
David G. Cornwell, Fred A. Kruger, Haynes B. Robinson   +2 more
doaj   +1 more source

Effect of surfactants on liquid side mass transfer coefficients: a new insight [PDF]

, 2009
Specific experiments are proposed to investigate the effect of surfactants on liquid side mass transfer coefficients. They are based on the determination of the liquid side mass transfer coefficient kL at a free gas-liquid interface, under controlled ...
Hebrard, Gilles, Loubière, Karine, Zeng, Jikun   +2 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Investigation of Stabilized Amorphous Solid Dispersions to Improve Oral Olaparib Absorption

Pharmaceutics
In this study, we investigated the formulation of stable solid dispersions to enhance the bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer characterized as a BCS class IV drug with low solubility and low ...
Taehan Yun, Sumin Lee, Seowan Yun, Daeyeong Cho, Kyuho Bang, Kyeongsoo Kim   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Colloidal Stability of Positively Charged Dispersions of Styrene and Acrylic Copolymers in the Presence of TiO₂ and CaCO₃

Colloids and Interfaces, 2019
Increasing antibiotic resistance of several pathogenic microorganisms calls for alternative approaches to prevent spreading of bacterial diseases. We propose to employ for this purpose coatings obtained from positively charged latex dispersions.
Kamil Wojciechowski, Małgorzata Gutarowicz, Kamil Janke, Ilona Jurek, Marcin Kaczorowski, Jolanta Mierzejewska, Paweł Parzuchowski   +6 more
doaj   +1 more source

The Electroviscous Behavior of Aqueous Dispersions of Amorphous Silica (Ludox)

, 2001
The electroviscous effects in very dilute aqueous dispersions of amorphous silica (Ludox) were investigated at various levels of salt, pH, and volume fraction
Laven, J., Stein, H.N., Stein, HN, Lavèn, J Jozua=Jos   +3 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source