Results 71 to 80 of about 1,625,274 (385)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Achieving extremely concentrated aqueous dispersions of graphene flakes and catalytically efficient graphene-metal nanoparticle hybrids with flavin mononucleotide as a high-performance stabilizer.

ACS Applied Materials and Interfaces, 2015
The stable dispersion of graphene flakes in an aqueous medium is highly desirable for the development of materials based on this two-dimensional carbon structure, but current production protocols that make use of a number of surfactants typically suffer ...
M. Ayán-Varela, J. I. Paredes, L. Guardia, S. Villar-Rodil, J. Munuera, María Díaz-González, César Fernández-Sánchez, A. Martínez-Alonso, J. Tascón   +8 more
semanticscholar   +1 more source

Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]

, 2019
The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B., Dave, Vivek S, Patil, Arun T., Pethe, Anil M., Raut, Nishikant, Telange, Darshan R., Umekar, Milind J.   +6 more
core   +1 more source

Aqueous Dispersions of Extraordinarily Small Polyethylene Nanoparticles [PDF]

Angewandte Chemie, 2004
Emulsion polymerization is among the most important polymerization processes. As a product, polymer latices that are stable colloidal aqueous dispersions of polymer particles of about 50 nm to 1 mm in size are obtained. About ten million tons annually of polymer latices are used for a variety of applications, such as environmentally friendly coatings ...
Kolb, L, Monteil, V, Thomann, R, Mecking, S   +3 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Ultrahigh concentration exfoliation and aqueous dispersion of few-layer graphene by excluded volume effect

Nature Communications
Colloidal properties of nanoparticles are intricately linked to their morphology. Traditionally, achieving high-concentration dispersions of two-dimensional (2D) nanosheets has proven challenging as they tend to agglomerate or re-stack under increased ...
Zhiyuan Xiong, Luyan Shen, Jin Long, Xiao Li, Ke Zhou, Gyeong Min Choi, Kangtai Ou, GuiYan Yang, Weichun Ma, Heon Sang Lee, Youyi Sun, Dan Li   +11 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Photo-stability of lutein in surfactant-free lutein-zein composite colloidal particles

Food Chemistry: X, 2020
The ability of nanoparticles from the plant protein zein to protect lutein from light degradation was studied under various conditions. Lutein-zein nanoparticles were synthesized, after zein purification, by anti-solvent precipitation.
Frankjen Ynske de Boer, Arnout Imhof, Krassimir Petkov Velikov   +2 more
doaj   +1 more source

Bioinspired inhibition of aggregation in metal-organic frameworks (MOFs)

iScience, 2023
Summary: Different from traditional procedures of using solid stabilizers like polymers and surfactants, here we demonstrate that water, as a very “soft” matter, could function as a “spacer” to prevent the aggregation of metal-organic frameworks (MOFs ...
Licheng Yu, Zhihao Nie, Sicong Xie, Lili Jiang, Baokai Xia, Ming Li, Chi Cheng, Jingjing Duan, Markus Antonietti, Sheng Chen   +9 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source