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Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

open access: yesMedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

open access: yesMedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu   +5 more
wiley   +1 more source

Development of a Novel Polyleucine‐Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus

open access: yesSmall, Volume 22, Issue 22, 17 April 2026.
Self‐assembling amphiphilic peptide L15K6 is used as a novel immunoadjuvant for the development of a Group A Streptococcus vaccine. Robust antigen‐specific IgG responses are generated and manage to kill isolated strains of Group A Streptococcus. Cellular and bulk RNA sequencing data reveals that L15K6 regulates immune responses potentially through TLR ...
Lantian Lu   +25 more
wiley   +1 more source

Hypomethylation of thrombospondin-1 promoter region is associated with reduced aqueous humor flow. [PDF]

open access: yesCommun Biol
Choy KY   +9 more
europepmc   +1 more source

Neighboring Ridgetops With Distinct Weathering Drivers Have Strikingly Similar Saprolite Chemical Weathering

open access: yesJournal of Geophysical Research: Earth Surface, Volume 131, Issue 4, April 2026.
Abstract Chemical weathering, and the subsequent porosity it generates controls soil development, water cycling, and nutrient availability. However, predicting spatial variability in chemical weathering remains challenging due to complex interactions between dominant drivers including climate, topography, water cycling, and vegetation dynamics.
Amanda Donaldson   +5 more
wiley   +1 more source

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