Results 31 to 40 of about 1,217,652 (278)

REEL SEKTÖR FİRMALARINDA ARGE FAALİYETLERİNİN FİNANSAL PERFORMANS ÜZERİNE ETKİSİ: TÜRKİYE’DEN KANITLAR

KAÜ-İİBF Dergisi, 2023
Son yıllarda küreselleşmenin etkisinin giderek artması ve beraberinde ortaya çıkan yüksek rekabet ortamı, sürekli olarak artan tüketici talepleri, teknolojik gelişmeler vb. firmaları inovatif faaliyetlere yönlendirmektedir.
Hakan Yıldırım
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Türkiye’de Ar-Ge vergi teşviklerinin etkinliği

, 2021
The aim of this study is to investigate the effectiveness of research and development (R&D) tax incentives in generating additional business R&D expenditures in Turkey by applying propensity score matching (PSM) to correct any selection bias and to ...
Taş, Ekin
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Determination of Caffeine in Human Plasma by Using Liquid Chromatography-Tandem Mass Spectrometry

Cumhuriyet Science Journal, 2023
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine caffeine (CAF) in human plasma. The plasma samples were extracted by protein precipitation using CAF-D3 as an internal standard (IS).
Fırat Yerlikaya, Onursal Sağlam
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

YÜKSEK DERİŞİMDE FOSFORÖZ ASİTTEN POTASYUM FOSFİT TUZLARI ÜRETİMİNDE REAKTÖR İŞLETİM TÜRÜNÜN ETKİSİ

Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, 2021
In the production of potassium phosphite salts (monopotassium phosphite and dipotassium phosphite salts) formed as a result of the neutralization reaction of phosphorous acid and potassium hydroxide.
Zeynep YILMAZER HİTİT, Pınar AYGENER, Elçin Elmas AK, Kemal KESENCİ, Suna ERTUNÇ, Bülent AKAY   +5 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Ar-Ge ve Yeniliğin Ölçümü ve Ar-Ge ve Yenilik Anketi Verilerinin Araştırmada Kullanılması [PDF]

, 2016
1980’lerde evrimci iktisat yazını ve 1990’larda neo-klasik içsel büyüme modelleri Ar-Ge ve yeniliğin önemini ortaya koymuştur. Bu etkinin tam olarak anlaşılması ve analiz edilebilmesi, Ar-Ge ve yeniliğin doğru ve sistematik bir şekilde ölçülmesine ...
Kalaycı, Elif, Akçomak, İbrahim Semih
core