ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. [PDF]
, 2016 The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined.
Borowsky, Alexander D +17 more
core +2 more sources
Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection. [PDF]
, 2013 To test, whether 10 genes, diagnostic of renal allograft rejection in blood, are able to diagnose and predict cardiac allograft rejection, we analyzed 250 blood samples from heart transplant recipients with and without acute rejection (AR) and with ...
Hsieh, Szu-Chuan +9 more
core +5 more sources
Niclosamide enhances abiraterone treatment via inhibition of androgen receptor variants in castration resistant prostate cancer. [PDF]
, 2016 Considerable evidence from both clinical and experimental studies suggests that androgen receptor variants, particularly androgen receptor variant 7 (AR-V7), are critical in the induction of resistance to enzalutamide and abiraterone.
Armstrong, Cameron +4 more
core +1 more source
Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. [PDF]
, 2019 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Prior studies have highlighted the importance of AR nuclear localization in SBMA pathogenesis; therefore, in ...
Arnold, Frederick J. +2 more
core +3 more sources
Investigating genetic predisposition to premature decline in ovarian reserve
Акушерство, гинекология и репродукция, 2022 Introduction. Normal ovarian reserve (OR) determining the ovarian response to follicle development containing fully-featured oocytes is an important factor in pregnancy, including assisted reproductive technology (ART) programs.
E. V. Kudryavtseva +3 more
doaj +1 more source
Review of Economics and Statistics, 2008 We examine Becker's (1960) contention that children are "normal." For the cross section of non-Hispanic white married couples in the U.S., we show that when we restrict comparisons to similarly-educated women living in similarly-expensive locations, completed fertility is positively correlated with the husband's income.
Black, Dan A. +3 more
openaire +9 more sources
Idioms are Oblivious, Arrows are Meticulous, Monads are Promiscuous [PDF]
Electronic Notes in Theoretical Computer Science, 2011 AbstractWe revisit the connection between three notions of computation: Moggiʼs monads, Hughesʼs arrows and McBride and Patersonʼs idioms (also called applicative functors). We show that idioms are equivalent to arrows that satisfy the type isomorphism A↝B≃1↝(A→B) and that monads are equivalent to arrows that satisfy the type isomorphism A↝B≃A→(1↝B ...
Lindley, Sam +2 more
openaire +3 more sources
Grain boundary partitioning of Ar and He [PDF]
, 2007 An experimental procedure has been developed that permits measurement of the partitioning of Ar and He between crystal interiors and the intergranular medium (ITM) that surrounds them in synthetic melt-free polycrystalline diopside aggregates.
Asimow, Paul D. +2 more
core +2 more sources
Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients [PDF]
, 2016 Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of
Edwards, J. +7 more
core +1 more source
A spectroscopic study of the cycling transition 4s[3/2]_2-4p[5/2]_3 at 811.8 nm in Ar-39: Hyperfine structure and isotope shift [PDF]
, 2010 Doppler-free saturated absorption spectroscopy is performed on an enriched radioactive Ar-39 sample. The spectrum of the 3s^2 3p^5 4s [3/2]_2 - 3s^2 3p^5 4p [5/2]_3 cycling transition at 811.8 nm is recorded, and its isotope shift between Ar-39 and Ar-40
Lu, Z. -T. +5 more
core +3 more sources