Results 71 to 80 of about 383,160 (312)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Human α(2)β(1)(HI) CD133(+VE) epithelial prostate stem cells express low levels of active androgen receptor.

PLoS ONE, 2012
Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
Stuart C Williamson, Anastasia C Hepburn, Laura Wilson, Kelly Coffey, Claudia A Ryan-Munden, Deepali Pal, Hing Y Leung, Craig N Robson, Rakesh Heer   +8 more
doaj   +1 more source

Downregulation of β-Adrenoceptors in Isoproterenol-Induced Cardiac Remodeling through HuR. [PDF]

PLoS ONE, 2016
β-adrenergic receptors (β-ARs) play an important role in cardiac remodeling, which is the key pathological process in various heart diseases and leads to heart failure.
Qian Yin, Chengzhi Yang, Jimin Wu, Haiyan Lu, Xiaohui Zheng, Youyi Zhang, Zhizhen Lv, Xiaopu Zheng, Zijian Li   +8 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of Electroacupuncture at "Futu" (LI 18) on the Immunoactivity of Substance P,5-HT1 AR,etc.of the Cervical Spinal Dorsal Horn in Rats with Neck Incision Pain

针刺研究, 2010
Objective To observe the effect of electroacupuncture(EA) of bilateral "Futu"(LI 18) on the immunoactivity of substance P(SP),NK-1 receptor(R),cyclooxygenase-1(COX-1),5-HT 1 AR and 5-HT 2 AR in the cervical spinal dorsal horn of rats with neck incision ...
QIAO Li-na, WANG Jun-ying, CHEN Shu-ping, GAO Yong-hui, YANG Yong-sheng, LIU Jun-ling   +5 more
doaj  

Analysis of Risk Factors for Anastomotic Leakage After Laparoscopic Anterior Resection of Rectal Cancer and Construction of a Nomogram Prediction Model

Cancer Management and Research, 2022
Keli Wang,1 Meijiao Li,1 Rui Liu,1 Yang Ji,2 Jin Yan1,3 1Department of Clinical Medicine, Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Clinical Medicine, University of Electronic Science and Technology of China ...
Wang K, Li M, Liu R, Ji Y, Yan J
doaj  

Preference Erosion: The case of Bangladesh - A SUR-EC-AR Gravity Model of Trade [PDF]

This paper analyses the impact of preference erosion on Bangladesh’s clothing industry coming from both the ATC quotas phasing-out and the reduction on MFN tariffs under NAMA negotiations. First, it undertakes a numerical exercise to estimate the effects
Erika Vianna Grossrieder
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Macroeconomic forecasting using model averaging

, 2009
PhDRecently, there has been a broadening concern on forecasting techniques that are applied on large data sets, since economists in business and management want to deal with the great magnitude of information. In this analysis, the issue of forecasting
Verra, Christina
core